•Operate and maintain production bioreactors ranging in scale from 2L glass vessels, to 100L single use toxicology batches • Serve on the upstream CMC team for multiple late-stage clinical candidates • Manage internal projects from early-stage clone selection and material generation, through Ph1-Ph3 process development while collaborating with the downstream and analytical teams • Perform tech transfers to partner CMOs and oversee GMP productions in 5k and 15k liter bioreactors • Author all relevant technical reports, protocols, and batch records • Provide mentorship to new hires on job activities and data analysis

Process Development & Engineering, BioProcess Development, Kenilworth NJUpstream Process Development and Media Development• Work to achieve high bioreactor titer through high-intensity cell culture processes including N-1 perfusion, concentrated fed-batch, and perfusion cultures.• Support Ph1 to Ph3 process development studies in ambr15/ambr250 microbioreactors.• Assess new media and feed strategies with the goal of improving the platform fed-batch process.• Collaborated on the development of an automated high throughput FACS analysis method to monitor intracellular levels of monoclonal antibody chains.• Utilized DOE tools as part of a team effort to develop an in-house proprietary cell culture medium.• Present findings in group, department, and national meetings.

• BioProcess Development and Engineering Group of Merck Research Labs• Assessment and enhancement of cell line stability through process development and medium optimization• Examined cell metabolism differences between stable and unstable cell lines and investigate the opportunity to enhance cell line stability through medium and/or process optimization

• Investigated effects of plasma generated ROS on cellular processes• Designed phagocytosis assay to measure lipoparticle uptake into macrophage cells dosed with plasma

• Supported daily processes in an ISO-5 cleanroom• Performed monthly cleaning of incubators and refrigerators• Ensured proper cryogenic storage and retrival of harvested cells in LN2• Assisted with Growth Promotion studies by feeding, passaging, and harvesting cell stacks• Processed autologous skin care cream using proteins derived from personal fibroblast cells• Adhered to GMP standards and documentation

• Investigated effects of small heat shock protein 27 (Hsp27) on radioresistance of colon adenocarcinoma cells• Collaborated with researchers to study targeted knockdown effects of LNA-based therapy• Presented significant findings at weekly lab meetings• Contributed data sets included in article for publication