Andrew Russo Email and Phone Number
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Scientist with 22 years experience identifying and selecting targets, conducting early in-vitro development, and performing in-vivo pre-clinical testing. Multi-disciplinary expertise in molecular biology, biochemistry, and protein engineering, with experience in many analytical techniques including HPLC, CE, spectrophotometric assays, SDS-PAGE, ELISA, and light scattering.Results-oriented leader skilled in equipping and empowering teams of research technicians and scientists to execute diverse projects in biotechnology. Recognized for creativity, productivity, and history of quickly making significant technical, tactical, and strategic contributions. SKILLS & CAPABILITIES INCLUDE: Conducting bench activities for protein analytical characterization of new drug candidates. Developing, optimizing, qualifying, and documenting test methods by generating study plans, protocols, standard operating plans, and reports. Ensuring regulatory compliance by creating and reviewing technical documents, such as analytical method development reports, method validation protocols and reports, and standard operating procedures. Collaborating with R&D departments to support testing of new drug candidates at various stages of development. Participating in technical transfer of assays to quality control, process development, and contract laboratories in GLP environments.AREAS OF EXPERTISE INCLUDE:Structure-Based Protein Engineering – Recombinant Protein Therapeutic Development – GLP Study Design & ManagementProtein Purification & Characterization – Project Management – Experimental Study Design – GLP / Regulatory Compliance Team Leadership – Research Collaborations – Grant & Proposal Development – Manuscript & Report Preparation Assay Development – Fluorescence Spectroscopy – Molecular Cloning – Macromolecular Analysis – Statistical Data AnalysisAnalytical & Preparative Chromatography – Animal Model Development – Biochemical Analysis – Immunoassay Methods
Siga Technologies
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Associate Director Of Animal StudiesSiga Technologies Jul 2022 - PresentNew York, Ny, Us
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Group Leader, Poxvirus ResearchSiga Technologies Jul 2016 - Aug 2022New York, Ny, Us
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Associate Scientist/Study DirectorLovelace Respiratory Research Institute Feb 2010 - Jul 2016Pre-clinical testing of medical countermeasures to infectious diseases with emphasis on viruses of interest in national defense and global public health.• Experienced in conduct of pivotal studies of vaccines and antiviral drugs in a GLP environment to be used in regulatory filings.• Directed teams of more than 15 individuals to complete multi-million dollar antiviral drug and vaccine efficacy programs on time and within budget.Infectious disease animal model development.• Experienced in multiple animal models of viral and fungal infection in small animals and NHP’s under ABSL-2 and ABSL- 3 enhanced containment levels.• Established two new models of distinct viral diseases and defined primary clinical endpoints for use in evaluation of medical countermeasures to these pathogens.Prepared proposals for submission to private industry and government sponsors for applied research contracts.
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Senior Research ScientistMolecular Logix Jul 2007 - Apr 2009• Developed an improved phospho-human epidermal growth factor receptor (HER) ELISA protocol that decreased reagent cost 50% compared to previous company protocol.• Produced milligram quantities of pan-HER ligand mutants in E. coli culture and purified soluble protein to >90%.• Directed laboratory technicians in the expression and characterization of mutant EGF pan-HER dominant negative ligand candidates and evaluation of candidate biological activity. • Prepared National Cancer Institute SBIR Phase I research plan for the development of cancer treatments based on engineering dominant negative ligands for fibroblast growth factor 2.• Designed point-mutations and deletion mutants in an epidermal growth factor based pan-HER ligand based on published studies of EGF mutants and examination of the EGF-EGFR crystal structure. • Developed a homology model of the heregulin-HER3 complex based on the published EGF-EGFR complex that was used to design point mutations in EGF to modulate binding to HER3.• Evaluated purity and quantity of pan-HER ligand mutants. • Identified anti-cancer pan-HER antagonists by screening over two dozen mutant EGF pan-HER dominant negative ligand candidates for receptor affinity and biological activity. • Developed polyethylene glycol (PEG) conjugation protocol to modify, which led to production of PEG-pan-HER dominant negative ligand constructs with improved pharmacological properties.
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Post Doctoral FellowUniversity Of Texas Medical Branch Oct 2002 - Feb 2007Postdoctoral Fellow nsP2 protease of Venezuelan equine encephalitis virus • Cloned, purified and biochemically characterized the nsP2 protease.• Solved the X-ray crystal structure of nsP2 protease (first nsP2 protease structure; novel fold identified).• Identified substrate specificity determinants from structural and molecular dynamic calculations.• High-throughput screening of nsP2 protease for potential inhibitors.ns3 protease from dengue virus• Identified small molecule inhibitors from in silico screening of ns3 protease• Designed cell-culture and in vitro assays to evaluate potency of predicted inhibitors.
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Post Doctoral FellowUniversity Of Texas Medical Branch Apr 2000 - Sep 2002Postdoctoral Fellow FK506-binding protein (FKBP12)• Expressed and purified FKBP12. • Investegated effects of osmolytes on FKBP12 stability (kinetic and thermodynamic characterization). Ribonuclease T1 (RNase T1)• Expressed and purified RNase T1.• Completed differential scanning calorimetry and urea denaturation studies.• Determined rank order of stabilization efficacy of protective osmolytes .
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Lab TechnicianThe University Of Medicine And Dentistry Of New Jersey Jan 1993 - Aug 1993Responsibilities included isoelectric focusing of unbleached bovine rhodopsin, silver stain of gels and laser densitometry to quantitate the different phosphorylation states present in the sample. Also responsible for quantitative assay of protein, lipid, and cholesterol in density gradient fractions of bovine rod cell outer segment membrane preparations
Andrew Russo Skills
Andrew Russo Education Details
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The Johns Hopkins UniversityBiology -
Rutgers University - CamdenBiology
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Rutgers University - CamdenBiology/Chemistry Minor
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Gloucester Catholic High SchoolHs Diploma
Frequently Asked Questions about Andrew Russo
What company does Andrew Russo work for?
Andrew Russo works for Siga Technologies
What is Andrew Russo's role at the current company?
Andrew Russo's current role is Associate Director, Animal Studies, Poxvirus Research at SIGA Technologies Inc..
What is Andrew Russo's email address?
Andrew Russo's email address is at****@****ail.com
What is Andrew Russo's direct phone number?
Andrew Russo's direct phone number is +140977*****
What schools did Andrew Russo attend?
Andrew Russo attended The Johns Hopkins University, Rutgers University - Camden, Rutgers University - Camden, Gloucester Catholic High School.
What are some of Andrew Russo's interests?
Andrew Russo has interest in Education, Environment, Science And Technology, Human Rights, Animal Welfare, Health.
What skills is Andrew Russo known for?
Andrew Russo has skills like Protein Chemistry, Biochemistry, Molecular Biology, Protein Purification, Biotechnology, Elisa, Cell, Laboratory, Animal Models, Protein Expression, Fluorescence, In Vitro.
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