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I have a fascination with protein chemistry, specifically understanding the link between structure and function. Structurally characterizing proteins provides a unique look at the "gears" of the biological machinery. Knowing how biology work at the atomic level will open new avenues to attack modern medical diseases.
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Sr. Director, Protein BiochemistryXaira Therapeutics Sep 2024 - PresentBrisbane, Ca, Us -
Research Fellow, Protein BiochemistryXaira Therapeutics Nov 2023 - Sep 2024Brisbane, Ca, Us -
Director Of BiologicsDren Bio, Inc. Jan 2022 - Oct 2023Foster City, California, Us -
Associate DirectorDren Bio, Inc. Sep 2020 - Dec 2021Foster City, California, UsBuilding infrastructure to protein expression, purification and engineering. DR-01 candidate selection to manufacturing at CDMODR-02 develop bispecific platform to allow POC for multiple targets -
Senior Research Investigator IiBristol Myers Squibb 2019 - Sep 2020Lawrence Township, Nj, UsInitiate and co-lead discovery projects for Immunology-OncologyMultiple cytokines oriented projects co-lead by groupFormed multi-disciplinary team to discover and engineer molecules for co-stimulatory pathways -
Scientist IiiBristol Myers Squibb 2018 - 2019Lawrence Township, Nj, UsInitiate and co-lead discovery projects for Immunology-OncologyDeveloped new capabilities within Protein Engineering to generate POC data -
Scientist IiBristol Myers Squibb 2016 - 2018Lawrence Township, Nj, UsCo-lead discovery projects for Immunology-OncologyDevelopment of myeloid CPITargeted cytokine delivery to tumor environment -
Scientist IBristol Myers Squibb 2015 - 2016Lawrence Township, Nj, UsDevelop checkpoint inhibitor therapy Tim-3 antagonist, FIH 2018 Antibody lead selection and optimization Provided structural insights and tested for MOA Develop assay based on MOA to better screen for functional antibodies Solved structure of lead antibody (fab) in complex with antigen -
Post Doctoral Research FellowPfizer Jun 2013 - Aug 2015New York, New York, UsAntibody engineering, display technology and protein structural studies. -
Graduate StudentUniversity Of Cincinnati Sep 2006 - May 2013Cincinnati, Ohio, UsThe lipid binding protein apolipoprotein A-IV (apoA-IV) has the unique distinction in beneficially affecting satiety, lipid metabolism, anti-inflammation, anti-oxidation and insulin secretion, all of which are important for combating obesity, cardiovascular disease and diabetes. My research has made substantial strides in understanding apoA-IV by: • Determining the first atomic-resolution structure of dimeric apoA-IV.• Proposing the first model of apoA-IV high-density lipoprotein (HDL).• Providing the first solution state envelops of apoA-IV as a monomer, dimer, and trimer.• Describing a unified mechanism of self-association, particle formation and maturation for apoA-IV. • Deriving specific mutations that enhance oligomeric stability and functionality. The structural and biophysical information resulted from my work will be essential in utilizing apoA-IV as a therapeutic agent in treating obesity-related comorbidities. -
Research AssistantUniversity Of Kentucky Nov 2005 - Jun 2006Lexington, Ky, UsUnderstanding role of nebulette in the cardiac sarcomere. -
InternMd Anderson Cancer Center May 2003 - Jul 2003Houston, Tx, UsDetailing apoptosis activation mechanism.
Andy Deng Skills
Andy Deng Education Details
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University Of Cincinnati College Of MedicineStructural Biology -
Beijing Language And Culture University -
University Of KentuckyBiotechnology
Frequently Asked Questions about Andy Deng
What company does Andy Deng work for?
Andy Deng works for Xaira Therapeutics
What is Andy Deng's role at the current company?
Andy Deng's current role is Senior Director.
What is Andy Deng's email address?
Andy Deng's email address is an****@****bms.com
What is Andy Deng's direct phone number?
Andy Deng's direct phone number is +151368*****
What schools did Andy Deng attend?
Andy Deng attended University Of Cincinnati College Of Medicine, Beijing Language And Culture University, University Of Kentucky.
What are some of Andy Deng's interests?
Andy Deng has interest in Skiing, Snow Boarding, Cycling, Adventure Races, Hiking, Running, Climbing.
What skills is Andy Deng known for?
Andy Deng has skills like X Ray Crystallography, Biophysics, Phage Display, Protein Purification, Molecular Biology, Biochemistry, Protein Chemistry, Cell Culture, Protein Expression.
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