Ann E. Lin, Phd Email & Phone Number

Morrisville, Nc, Us

Syneos Health (Previously INC/InVentiv) is the only fully integrated, end-to-end service CRO that accelerate drug development from pre-clinical, clinical, to commercialization. Early Phase services include:- Phase 1 studies in healthy volunteers (2 wholly owned and operated clinics in North America): Traditional SAD/MAD studies as well as adaptive design, phase 1b/2a hybrid studies, BA, BE, DDI, FE, TQT, and phase 2a proof of concept studies in CNS, renal/hepatic impairment dermatology, etc. - Bioanalytical work: preclinical and clinical assays (GLP certified laboratories): small and large molecules. - External global network in North America, Australia/New Zealand and Europe. - Regulatory supports (Canadian CTA/USA IND filing).

Beijing, Cn

Supporting clients in accelerating early drug phase 1 clinical trials and phase 2 proof of concept studies in Pharmaron’s US-based Clinical Pharmacology Center in Baltimore. Services provided including Regulatory Affair services (US FDA IND filing), First in human, hADME, BA/BE, FE, DDI, TQT studies in healthy volunteers.

San Diego, California, Us

Top BD achieved a historical 155% of target sales within company in 2020.Establishing and managing strategic key accounts. Working with large, mid- and small size pharmas and biotechs to accelerate their preclinical oncology programs to the clinic.

San Diego, California, Us

• Managing 50+ active accounts in the West coast territory. Promoting CrownBio's portfolio in oncology and inflammatory diseases. Presenting at client meetings and Lunch and Learns. • Scientific liaison and Client support: providing consultation and feedback to clients on study designs to help accelerate their pre-clinical drug discovery. • Working with operations and marketing on increasing internal R&D efforts.

San Diego, California, Us

San Diego, California, Us

Principal Investigator leading pre-clinical research in CAR-T, small molecules, antibodies and oncolytic viruses in PDX/CDX and syngeneic mouse models (humanized and non-humanized). My responsibilities include, but not limited to: • Scientific Liaison & Client Support: Consult clients on project scope, timeline and develop study designs for in vivo and in vitro I/O platforms prior or post- study kick off. Generate internal R&D marketing materials in collaboration with marketing directors. Contribute to Scientific Blog on CrownBio's website. • R&D: Spearhead R&D efforts via internal collaboration with Scientific Research and Innovation team. Initiate and lead external collaboration with other industry leaders (clients or CROs). • Management: Coordinate and direct in vivo Research Associate to execute client or internal R&D studies in a highly matrix environment. Lead in vitro cell line and PDX teams to optimize, streamline and standardize operation processes. Lead BD training sessions on new platforms offered at CBSD.

San Diego, California, Us

Lead R&D product development: Develop cell- based luciferase assays for immune checkpoints (ie. GITR, CD40, CD47, 4-1BB) in various cell lines. • Design and synthesize mammalian constructs and lentiviral constructs for DNA delivery into immune cells and epithelial cells.• Validating immune cell markers and in house fluorescent-labeled antibodies. • Maintain client relations : in vitro immuno-oncology compound screening- assists in identifying, clarifying and communicating issues with clients and recommend solutions. • Monitor and evaluate competitive products, industry standards, pre-clinical disciplines, and current/future trends. • Participates in decision-making regarding project plans and short-term research strategies.• Actively seek new technological platforms and identify new tools and products for cell-based compound screening; provides expert insight on feasibility of prospective projects.• Provide scientific progress reports, project timelines and long-term research project plans to the senior management / CEO of the company.

La Jolla, Ca, Us

• Pre-clinical immune-boosting drug evaluation against urinary tract infections and systemic bacterial infections. • Use molecular and cellular techniques to dissect molecular and immune signaling pathways to elucidate HIF-1 function and Human Milk Oligosaccharides targeting action on urinary tract infections in vitro and in vivo.• Investigate Caspase-1 dependent IL-1b activities in response to Group A Streptococcus and Pseudomonas infections using qRT-PCR, Western, IP, ELISAs, fluorescent microscopy and other phenotypic assays in mammalian cell culture, BMDM and in vivo models. • Supported by the Canadian Institute of Health Research (CIHR) Postdoctoral Fellowship.

La Jolla, Ca, Us

• Leading postdoc volunteers to organize networking events such as research symposiums• Working with biotech companies to sponsor postdoc association events and fundraisers• Managing annual budget • Spokesperson for postdoc networking events to promote the postdoc association

Burnaby, Bc, Ca

• Pre-clinical drug evaluation against gastrointestinal inflammation and infections. • Use RNAi, Western blots, IHC, IF and live-cell imaging to examine cytoskeletal and endocytic clathrin associated proteins in human intestinal epithelial cells and mouse GI tract in response to diarrhea-causing pathogens. • Examine the invasion mechanism of Francisella tularensis into non-phagocytic cells using inhibitor assays and confocal Microscopy. • Assess the role of ubiquitylation and post-translational modifications and signaling in host cell during GI pathogen infections. • Supported by CIHR and MSFHR senior graduate student fellowships.

Vancouver, British Columbia, Ca

• Use phenotypical, biochemical and cell based assays to examine a novel amino acid ABC transporter in Campyloabcter jejuni, and their impact on host immune cells during infections. • Supported by CIHR and MSFHR junior graduate student fellowships

Vancouver, British Columbia, Ca

• Use of C. rodentium as an in vivo diarrhea model to study the effect of attaching and effacing pathogen infection on gap junctions in host intestinal epithelial cells. • Investigate the role of intracellular junction desmosome and endocytic protein clathrin during Enteropathogenic E. coli pathogenesis.• Techniques include oral inoculation of C. rodentium to establish diarrhea-like infection in mice. Immunofluorescent microscopy and Western blot.

Vancouver, British Columbia, Ca

• Examine the effect of an oncogene Abelson helper integration site 1 (Ahi-1) suppression in Lymphoid and Myeloid leukemic cell lines. • Techniques utilized includes: T- cell and myeloid cell culture, proliferation assays, flow cytometry (FACS), real-time qPCR, cell forming colony (CFC) counts and proliferation assay using [3H]thymidine.

Vancouver, British Columbia, Ca

• Investigate quinolone resistant mechanism in community acquired MRSA.• Techniques involved 16sRNA sequencing combined with bioinformatic analysis. Routinely performed multiple antibiotic susceptibility assays. • Support by the CIHR-UBC TRID (translational research in infectious diseases) fellowship.

Micro- Mba

Doctor Of Philosophy (Phd), Biology/Biological Sciences, General

Master Of Science (M.Sc.), Microbiology And Immunology

Bachelor Of Science Honours (B.Sc. Hon), Biochemistry And Molecular Biology