Anna Azarova Email & Phone Number

Moscow, Russian Federation

• Preparation of the analytical summary for a prospective drug candidate, including scientific, clinical and marketing potential.• Patent search and preparation of reports on patentability of the medicinal products.• Investigational Medicinal Product Dossier preparation.• Collaboration with external partners and contractors on the project.

Greater Philadelphia Area

• Led a research project to study anticancer versus leukemogenic effect of commonly used chemotherapeutic drugs.• Systematically organized and managed a large data set using spreadsheets.

• Identified a novel treatment strategy for the high risk, treatment-resistant neuroblastoma.• Designed and carried out a high throughput gene expression studies to identify the key molecular pathways activated by the mutant receptor tyrosine kinase in neuroblastoma.• Created a molecular signature of the constitutively active receptor tyrosine kinase in neuroblastoma cell lines, where kinase signaling is abrogated by either genetic or pharmacological means.• Established cell lines to study mechanisms of resistance of Anaplastic Lymphoma Kinase-mutant neuroblastomas.• Successfully established and led multiple research projects.• Independently prepared and wrote a successful grant application that provided funding for two years.• Supervised and managed research technician, resulting in scientific publication (manuscript in preparation). • Established scientific collaborations between several research groups resulting in a scientific publication (manuscript in preparation).

• Developed a research project and designed experiments to study the differential role of the topoisomerase II isozymes in carcinogenesis using a skin-specific knockout mouse model.• Collected, managed and performed statistical analysis of data from the large research study.• Characterized DNA topoisomerase IIbeta protein expression using immunohistochemistry and Western blot analysis.• Studied a proteasome pathway for the repair of the topoisomerase II-DNA covalent complexes.• Investigated the role of Topoisomerase IIbeta in neurite outgrowth using primary neuron cultures, RT-PCR and Western blotting.