Providing clinical leadership in the global development of asset strategy and clinical development plan for assigned assets, within a cross-functional matrix environment, alongside functional areas including Commercial, Regulatory Affairs, Statistics, Medical Affairs, Global Clinical Operations, Medical Writing, Pharmacovigilance, Real World Evidence and Health Outcomes, pre-clinical Discovery, and Chemistry Manufacturing and Controls. Providing clinical oversight for global development projects, and functions independently in the daily management of clinical research studies. Securing, managing and maintaining critical partnerships with key business partners; interface professionally with a wide spectrum of internal and external stakeholder.

Leading of a team of Clinical Pharmacologists, overall responsible for early clinical development of innovative projects with both small molecules and biologic drug candidates. Integrating scientific, non-clinical, clinical, regulatory, translational and pharmacometrics aspects. Driving high quality of Clinical Pharmacology deliverables, lead change aimed at improving the efficiency of studies and to foster and implement innovative state-of-art methodologies in clinical pharmacology/early phase clinical research.

Associate Director, Clinical Pharmacology Team Leader and New Therapeutic Entities (NTE) PK/PD Evaluations Leader - Managing and leading a team of Clinical Pharmacologists, overall responsibilities for Clinical Pharmacology and Pharmacometrics development of innovative projects (NCEs). Responsible for the clinical pharmacology strategy, planning, direction, execution and interpretation of clinical pharmacology studies. Application of model based drug development concepts to impact decision making. Close collaboration with pre-clinical, clinical, regulatory, biometrics and project leadership departments, external consultants and KOLs, managing CROs. Accountable for all PK/PD aspects of NTE projects under screening and evaluation prior to approval for development, leading internal evaluation team, close collaboration with Generic an InnoTech business units and evaluations project leaders on assessment outcomes/deliverables. Responsibility for setting processes and standards for PK/PD evaluations, developing methods to enrich and improve assessment outcomes.

Clinical development of innovative drugs. Design and lead phase-1 and clinical pharmacology studies according to global regulatory requirements and internal procedures. Provide clinical pharmacology support to Phase 2-3 clinical trials. Lead pharmacokinetic (PK), population PK and PKPD analyses. Support clinical pharmacology aspects of regulatory submissions/interactions. Participation in product life cycle activities. Providing clinical pharmacology input for innovative products and companies under evaluation (due diligence).

Leading the formulation department responsible for formulation research and development of parenteral, oral, dental, and topical dosage forms for pre-clinical and phases I-II clinical trials. Leading and managing profitable cross-departmental projects, maintaining close communication with customer to ensure contentment throughout all stages of contracted projects.

Pharmaceutical approaches for enhancement of bioavailability of lipophilic molecules (Supervisor: Prof. Amnon Hoffman).

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Lab Instructor for B.Pharm 3rd year students

Coordinating the academic and logistic aspects of the newly established PharmD program at the School of Pharmacy.