Studying the role of mutations in KRAS in colon cancer. Scientist II at Dr. Kevin Haigis lab.

Establishing embryo in uterus 3D organ-on-chip model using primary stromal fibroblasts and epithelial cells. Testing the effects of SARS-CoV-2 on stromal fibroblasts decidualization.

Course director and lecturer - The Central Regulation of Bone and Energy Metabolism

In the lab of Prof. Roland Baron, we investigate the AP-1 dependent central pathways regulating energy metabolism and bone formation. Utilizing viral mediated gene transfer and transgenic mice models we modulate AP-1 factors, such as FosB splice variants, in specific areas of the brain with a goal of identifying the key neuronal circuits involved in the control of energy expenditure, bone formation, or both processes. We focus on studying the physiological parameters – energy expenditure, insulin sensitivity, bone architecture, and cellular/molecular mechanisms underlying these effects

Early Cell develops methods for the isolation of circulating fetal and cancer cells of high clinical significance

Under the supervision of Dr. Efrat Monsonego Ornan investigated the role of Bone Gla Protein (BGP, Osteocalcin) in glucose metabolism and calcification of cartilage and vasculature Studied the effect of active Vitamin D metabolite, 1,25(OH)2D3 on the development of cartilage and bones

Instructed the Human Nutrition Laboratory and Tutorial courses, composed and graded exams, participated in course curriculum development

Involved in company's business development, establishing connections with key global industry playersPresented company at national and international conferences reaching to a broad audience of biotechnology, pharmaceutical and investor representativesEdited business plan, conducted market analysis and competitor evaluation, composed science- and business – oriented presentations, press releases, and executive summaries Participated in negotiating the terms of joint R&D dealsCarried responsibility for the complete renovation of company’s website

Established and implemented High Throughput Screening (HTS) technologies for the discovery and development of novel small molecule therapeutics targeting the ubiquitin proteasome system (UPS)Developed and validated an arsenal of sensitive cell-free and cell-based bioassays (FRET (HTRF), ELISA, FP) for the measurement of ubiquitination and binding activity of the UPS components. Adopted these technologies to the robotic HTS platform. Designed and conducted screening against diverse chemical libraries, followed by hit analysis, confirmation, and validation proceduresParticipated in the biological research, identifying new correlations between UPS and pathological conditions

Established assays for Absorption, Distribution, Metabolism, Excretion (ADME) and early Toxicity profiling of chemical leads offered as drug discovery servicesIn vitro: cell permeability, plasma protein binding, metabolic stability in hepatocytes, plasma stability, cytotoxicity. In vivo: CSF collection, microdialysis Designed strategy and optimized protocols helping pharmaceutical clients to accelerate the transition of lead compounds to clinical candidates in a timely mannerDesigned computational models for data collection and analysis

Worked at Dr. Dusica Maysinger’s lab on the underlying mechanisms of pancreatic islet cell death and long term complications in diabetesInvestigated the cellular effects of Paclitaxel-induced neuropathy

Worked under supervision of Dr. Jean DaSilva. Thesis title: Studying the binding of Phosphodiesterase-4 Inhibitor R-[11C]Rolipram in Rat Brain: Effects of Glutamatergic Modulation on Various Neurotransmitter Systems and Validation Binding AssaysEvaluated the effects of treatment with cAMP modulating drugs on brain distribution of potential Positron Emission Tomography (PET) tracer

Worked under the supervision of Dr. Jane Mitchell on the effects of Glucocorticoid treatment on Gq/11 protein expression

Participated in a research program investigating the physiological effects of combat (strenuous activity, sleep deprivation, and heat) on women in the army