Anna-Karin Sternbeck Email & Phone Number

Experienced scientist with a demonstrated history of working in the pharmaceutical industry. Many years' experiences of discovery and early development work in the roles as a Principal Scientist, Team Leader and Preclinical DMPK Project Leader. Since 2019 a researcher at the Research Institutes of Sweden. Customer-oriented with commitment to reaching project goals in an interdisciplinary environment. Experience includes:• Collaboration across disciplines• Coordination of studies during project progression• Outsourcing of studies• ADME support and guidance to customers• In silico predictions of physicochemical and ADME parameters• Analysis of pharmacokinetic parameters• Toxicokinetic evaluations according to Good Laboratory Practice (GLP)• Extensive experience of in vitro and in vivo ADME studies and of physicochemical studies• Method development and optimization• DMPK strategy planning and implementation• Prediction of in vivo clearance from in vitro parameters• Early dose to man predictions based on integration of data in the discovery phase• Evaluation of drug-drug interactions in vitro and in vivo• Extensive use of Phoenix WinNonlin, ADMET predictor, GastroPlus and D360• Study director for in vitro and in vivo studies• Documentation and report writing• Excel template development, e.g., for data reporting, result handling and calculations, as well as templates for planning of activities• Teaching• Supervision of students and junior scientists• Peer reviewer of scientific manuscripts• Preclinical DMPK project leadership• Science team leadershipExamples of achievements:• Active role in several project transitions• A leading role in the standardization and implementation of a strategy for in vitro to in vivo prediction of clearance globally within AstraZeneca (a cross-site project)• Actively involved harmonization and implementation of DMPK strategies, globally within AstraZeneca (a cross-site project)• Led the development and implementation of a strategy for reactive metabolites at Medivir

Listed skills include Adme, Dmpk, Team Leadership, Teamwork, and 42 others.