Anna Knize Email & Phone Number

California, United States

San Diego, California, United States

Greater San Diego Area

San Diego

• Biomarker Assay for Phase 1 Clinical Trialo Responsible for development, validation, and execution of an LC/MS based substrate hydrolysis biomarker assay in human patient peripheral blood mononuclear cells
• Human Whole Blood Functional Assays Leado Established and executed hWB assays for ex vivo analysis of small molecule IC50’s, time dependent activity, reversibility, and enzyme recovery o Determined risk profile of.
• Metabolomics, LC/MSo Profiled lipid metabolites treated with small molecule enzyme inhibitors in CNS and peripheral tissues for multiple programso Managed and trained staff in lipid metabolite extraction techniques and.
• Disease Patient sample profilingo Lead the characterization of inflammatory cytokine expression and lipid metabolites in human CSF from Alzheimer’s Disease patients o Evaluated serine hydrolase enzymes in Inflammatory.

San Diego, California

3545 John Hopkins Ct. #250

• Evaluated a murine bispecific biologic inhibitor as a potential treatment for autoimmune disease. Bispecific inhibitor was tested in a sheep red blood cell challenge model and NZB/NZW lupus model with endpoint analysis.
• Developed assays for target validation studies and compound screening of small molecules utilizing human T and B cells and murine B cells for Ig class switch analysis
• Evaluated T and B Cell regulation in human tonsil, spleen, lymph node, and PBMCs
• Responsible for comparing the effects of antibody candidates through cytokine, immunoglobulin, and drug serum levels by ELISA and MSD

• Led the co-culturing of stem cells and organotypic hippocampal slice cultures to study the integration of grafted cells with host tissue by way of immunofluorescent cell labeling
• Facilitated the implantation, replacement, and maintenance of subcutaneous osmotic pumps in mice for a collaborative study of the efficacy of a drug treatment candidate
• Responsible for evaluating electrophysiological properties of neuronally differentiated human bone marrow stem cells by whole cell patch clamp
• Isolation of rat organotypic hippocampal slice culture and primary neurons to study neuroprotection and synaptic plasticity
• Responsible for sectioning, staining, treatment, and analysis of fresh frozen rat brain for in situ analysis of neuroprotective treatments

• Participated in development and optimization of cell sorting and culturing techniques of human bone marrow for adult pluripotent stem cells using FACS analysis and antibody recognition techniques
• Developed and conducted molecular analysis for cell characterization of pluripotent stem cells
• Responsible for presentation of research data at weekly meetings to executive management