Relevant publications:Coll M, Ariño S, Mártinez-Sánchez C, Garcia-Pras E, Gallego J, Moles A, Aguilar-Bravo B, Blaya D, Vallverdú J, Rubio-Tomás T, Lozano JJ, Pose E, Graupera I, Fernández-Vidal A, Pol A, Bataller R, Geng J-G, Ginès P, Fernandez M, Sancho-Bru P. Ductular reaction promotes intrahepatic angiogenesis via Slit2-Robo1 signaling. Hepatology. 2022 Feb;75(2):353-368Ruiz Blázquez P, Pistorio V, Fernández-Fernández M, Moles A. The multifaceted role of cathepsins in liver… Show more Relevant publications:Coll M, Ariño S, Mártinez-Sánchez C, Garcia-Pras E, Gallego J, Moles A, Aguilar-Bravo B, Blaya D, Vallverdú J, Rubio-Tomás T, Lozano JJ, Pose E, Graupera I, Fernández-Vidal A, Pol A, Bataller R, Geng J-G, Ginès P, Fernandez M, Sancho-Bru P. Ductular reaction promotes intrahepatic angiogenesis via Slit2-Robo1 signaling. Hepatology. 2022 Feb;75(2):353-368Ruiz Blázquez P, Pistorio V, Fernández-Fernández M, Moles A. The multifaceted role of cathepsins in liver disease. J Hepatol. 2021 Nov;75(5):1192-1202. Alari-Pahissa E, Ataya M, Moraitis I, Campos-Ruiz M, Altadill M, Muntasell A, Moles A, López-Botet M. NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake. PLoS Pathog. 2021 Aug 20;17(8):e1009868. IF: 6.218 Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. Show less

Relevant publications (See Publications section below):De Pasquale V, Moles A*, Pavone LM*. Cathepsins as a novel target for the therapy of mucopolysaccharidoses. Cells. 2020 Apr; 9(4): 979.Ferreras L, Moles A, Situmorang GR, El Masri R, Wilson IL, Cooke K, Thompson E, Kusche-Gullberg M, Vivès RR, Sheerin NS, Ali S. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Biochim Biophys Acta Gen Subj. 2019 May;1863(5):839-848. Martínez-Fábregas… Show more Relevant publications (See Publications section below):De Pasquale V, Moles A*, Pavone LM*. Cathepsins as a novel target for the therapy of mucopolysaccharidoses. Cells. 2020 Apr; 9(4): 979.Ferreras L, Moles A, Situmorang GR, El Masri R, Wilson IL, Cooke K, Thompson E, Kusche-Gullberg M, Vivès RR, Sheerin NS, Ali S. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Biochim Biophys Acta Gen Subj. 2019 May;1863(5):839-848. Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated, STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018 Dec 17;9(1):5343. Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity. Front Pharmacol. 2018 May 15;9:453. Review. Show less

I am currently a PI within the Fibrosis Lab at Newcastle University. My translational research focuses on identifying new therapeutic targets to design new and better drugs for liver and kidney disease treatment. I am particularly interested in the cellular and molecular pathways driving disease progression, with an emphasis on protease biology.Relevant publications (See Publications section below):Cocchiaro P, De Pasquale V, Della Morte R, Tafuri S, Avallone L, Pizard A,… Show more I am currently a PI within the Fibrosis Lab at Newcastle University. My translational research focuses on identifying new therapeutic targets to design new and better drugs for liver and kidney disease treatment. I am particularly interested in the cellular and molecular pathways driving disease progression, with an emphasis on protease biology.Relevant publications (See Publications section below):Cocchiaro P, De Pasquale V, Della Morte R, Tafuri S, Avallone L, Pizard A, Pavone LM, Moles A. The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease. Front Cell Dev Biol. 2017 Dec 19;5:114. doi: 10.3389/fcell.2017.00114Fearn A, Situmorang GR, Fox C, Oakley F, Howarth R, Wilson CL, Kiosia A, Robson MG, Mann DA, , Sheerin NS, Moles A. The NF-κB1 is a key regulator of acute but not chronic renal injury. Cell Death Dis. 2017 Jun 15;8(6):e2883.de Mingo Á, de Gregorio E, Moles A, Tarrats N, Tutusaus A, Colell A, Fernandez-Checa JC, Morales A, Marí M. Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation. Cell Death Dis. 2016 Nov 10;7(11):e2464. Cocchiaro P, Fox C, Tregidgo, NW, Howarth R, Wood KM, Situmorang GR, Pavone L, Sheerin NS, Moles A. Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury. Sci. Rep. 2016 Jun 7;6:27112.Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS, Moles A. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep. 2016 Feb 2;6:20101. doi: 10.1038/srep20101.Moles A, Butterworth JA, Sanchez A, Hunter JE, Leslie J, Sellier H, Tiniakos D, Cockell SJ, Mann DA, Oakley F, Perkins ND. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. Oncogene. 2016 Feb 8. doi: 10.1038/onc.2015.526 Show less

As a Research Associate of the Fibrosis Laboratory team I focused my research on the study of NF-kappaB as a common regulator of fibrotic diseases (skin, lung and liver). Relevant publications (See Publications section below):Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the… Show more As a Research Associate of the Fibrosis Laboratory team I focused my research on the study of NF-kappaB as a common regulator of fibrotic diseases (skin, lung and liver). Relevant publications (See Publications section below):Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.J Hepatol. 2014 Apr;60(4):782-91.Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA, Perkins ND, Burt AD, Mann DA, Oakley F. Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology. 2013 Feb;57(2):817-28. Fullard N, Moles A, O'Reilly S, van Laar JM, Faini D, Diboll J, Reynolds NJ, Mann DA, Reichelt J, Oakley F. The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice. Am J Pathol. 2013.MR Ebrahimkhani, F Oakley, LB Murphy, J Mann, A Moles, MJ Perugorria, E Ellis, AF Lakey, AD Burt, A Douglass, MC Wright, SA White, F Jaffré, L Maroteaux, DA Mann. Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease. Nat Med. 2011 Nov 27;17(12):1668-73. Show less

As a recent postdoctoral fellow, I combined my expertise in liver fibrosis with the study of Niemann Pick Disease, a fatal storage lysosomal disorder.Relevant publications (See Publications section below):Moles A, Tarrats N, Fernández-Checa JC, Marí M. Cathepsin B Overexpression Due To Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann Pick Disease. J Biol Chem. 2012.Tarrats N, Moles A, Morales A, Garcia-Ruiz C, Fernández-Checa JC, Mari M. Critical role of… Show more As a recent postdoctoral fellow, I combined my expertise in liver fibrosis with the study of Niemann Pick Disease, a fatal storage lysosomal disorder.Relevant publications (See Publications section below):Moles A, Tarrats N, Fernández-Checa JC, Marí M. Cathepsin B Overexpression Due To Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann Pick Disease. J Biol Chem. 2012.Tarrats N, Moles A, Morales A, Garcia-Ruiz C, Fernández-Checa JC, Mari M. Critical role of TNF-receptor 1 but not 2 in hepatic stellate cell proliferation, extracellular matrix remodeling and liver fibrogenesis. Hepatology. 2011. Show less

My PhD research was focused on finding new therapeutic targets to tackle liver fibrosis, more particularly on the role that cathepsins and acidic sphingomyelinase have in this disease.Relevant publications (See Publications section below):Moles A, Tarrats N, Morales A, Dominguez M, Bataller R, Caballeria J, Garcia-Ruiz C, Fernández-Checa JC, Mari M. Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol. 2010.Moles… Show more My PhD research was focused on finding new therapeutic targets to tackle liver fibrosis, more particularly on the role that cathepsins and acidic sphingomyelinase have in this disease.Relevant publications (See Publications section below):Moles A, Tarrats N, Morales A, Dominguez M, Bataller R, Caballeria J, Garcia-Ruiz C, Fernández-Checa JC, Mari M. Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol. 2010.Moles A, Tarrats N, Fernández-Checa JC, Marí M. Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology, 2009.Marí M, Colell A, Morales A, Caballero F, Moles A, Fernández A, Terrones O, Basañez G, Antonsson B, García-Ruiz C, Fernández-Checa JC. Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology. 2008. Show less