Anna Sobieraj Email & Phone Number

Zurich, Switzerland

Horgen, Zurich, Switzerland

• Lead Optimization Expert Responsibilities:- Led the optimization of lead candidate compounds with focus on bispecific antibodies for immuno-oncology applications targeting solid tumors. Utilized sophisticated methods.
• Research Lead Responsibilities:- Led target assessment and evaluation initiatives, thoroughly analyzing target biology, unmet medical need, competitive landscape, and business opportunities, specifically within the.

Schlieren, Zurich, Switzerland

- Conducted antibody discovery campaigns from hit screening and identification, to lead optimization and clinical candidate selection. - Screened of phage display libraries to identify high-affinity, specific hits against diverse targets.- Generated high diversity phage display libraries for engineering and optimization of antibody fragments, focusing on.

Zürich Area, Switzerland

- Successfully engineered peptidoglycan-degrading enzymes to extend their serum circulation half-life and improved their in vivo efficacy. - Performed activity and stability tests, affinity measurements, PK/PD analyses of the engineered proteins and assessed their therapeutic potential in vivo in treatment of systemic drug-resistant S. aureus infections..

Zürich Area, Switzerland

- Designed and constructed novel engineered antimicrobial enzymes for treatment of intracellular S. aureus infections.- Expressed and purified recombinant proteins using Akta Purifier system (IEX chromatography and SEC).- Tested activity of the enzymes in vitro.

Zurich, Switzerland

Engineering of endolysins for targeting of intracellular Staphylococcus aureus: - Selection of candidate endolysins for fusion with cell penetrating peptides;- In-silico construction of protein expression vectors;- Molecular cloning;- Protein upstream and downstream processing;- Various functional activity assays in-vitro.

Wageningen

-Worked part-time on the application of bacteriophages for biocontrol of pathogens in food industry.-Provided support for the R&D team in bacteriophage isolation, characterization and production.-Reported to the Chief Scientific Officer,

Wageningen

-Worked independently on development of the bacteriophage-based product to fight thermophilic biofilm-forming bacterium for a third party.-Reported to the Chied Scientific Officer.

Rzgow

Internship in the Laboratory of White Cosmetics. Cooperated with the chief formulator in white cosmetics preparation and their stability testing.

Doctor Of Philosophy - Phd

Master'S Degree

Bachelor Of Science (B.Sc.)