Anne N. Murphy, Ph.D. Email and Phone Number
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Experienced biomedical scientist with a diverse history of leading innovative research teams in both academia and biopharmaceutical settings. Skilled in the study of mitochondria, metabolism, early stage drug and target discovery, biochemistry/cell biology, and management of preclinical research. Driven by the desire to improve the lives of patients with unmet medical needs by uniting those with diverse skills to solve complex biomedical problems. Currently an ambassador for building awareness of Cytokinetics' scientific excellence through strategic outreach, collaborations, and conferences. Highly motivated to foster the growth and recruitment of young scientists, stimulating rigorous and creative research, while also promoting diversity and equity in the biomedical research profession.
Cytokinetics
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Vice President Of BiologyCytokineticsSouth San Francisco, Ca, Us -
Vice President, Research AffairsCytokinetics Nov 2024 - PresentSouth San Francisco, California, Us• Act as a global scientific community ambassador for Cytokinetics, engaging with researchers and presenting at key conferences to enhance the company's reputation within the industry and scientific community. • Design and lead strategic initiatives aligning with Cytokinetics' commitment to scientific excellence.• Build collaborative relationships to drive scientific innovation within and beyond Cytokinetics. -
Vice President, BiologyCytokinetics Apr 2019 - Nov 2024South San Francisco, California, Us• Recruited to expand the portfolio of small molecule drug discovery programs beyond skeletal and cardiac muscle sarcomere targets to include metabolism/mitochondrial programs with a focus on therapeutic areas of heart failure [including heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF), hypertrophic cardiomyopathy (HCM), musculoskeletal disorders, and neuromuscular disease• Direct oversight of preclinical drug discovery efforts in Discovery Biology, Pharmacology, and Vivarium Services (30 - 44 FTEs) with total budget of approx. $22 million/yr• With matrix-team management of all preclinical programs, coordinate closely with leadership and members of medicinal chemistry, DMPK, and toxicology to design efficient progression of development candidates to IND submission• Responsible for target selection/validation, assay development, small molecule screening and optimization, translational studies in disease models, external innovation, and expansion of expertise and technologies to support pipeline growth• Typically managing 2-4 concurrent discovery programs at hit-to-lead, lead-op, candidate selection, or IND-enabling stage in matrix-teams from 4 to 26 scientists -
ProfessorUniversity Of California, San Diego Aug 2015 - Jun 2019My laboratory studied mitochondrial function and cell metabolism in the context of neurodegenerative and metabolic diseases. We focussed on the role of the substrate selection and oxidative capacity in the control of cell metabolism. We also developed approaches to expand insight into metabolism that can be obtained from the combination of high throughput respirometry with isotope tracing of energy substrates.
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Associate ProfessorUniversity Of California, San Diego 2005 - Aug 2015
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Director Of Mitochondrial BiologyMitokor 2000 - 2003Manager of Corporate Collaboration with Pfizer, a mitochondrial target-based collaboration for drug development in neurodegenerative disease. • Matrix Team Management of 12-15 biologists plus support chemists and lead discovery screening staff• Target identification, validation, establishment of high throughput assays relevant to particular mitochondrial targets• Establishment and oversight of compound screening for identification of candidate lead compounds • Coordination with MitoKor chemists for medicinal chemistry efforts to further probe structure/activity relationships in promising neuroprotective compounds; coordination of these efforts with further pre-clinical biological screening assaysChair, Degenerative Diseases Project Team (2000-2003)• Responsible for the design, optimization, and implementation of >10 high throughput assays that focussed on mitochondrial participation in cell death • Integration of biology team members into technology team for purposes of identification of the human mitochondrial proteome• Responsible for presentation of mitochondrial technologies, expertise, and internal research projects in frequent corporate partnering presentations nationally and internationally
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Associate Director Of Mitochondrial BiologyMitokor 1998 - 2000
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Assistant ProfessorThe George Washington University School Of Medicine And Health Sciences 1993 - 1998Research focused on the mitochondrial function of the anti-apoptotic protein Bcl-2. Medical and graduate school teaching on cell metabolism, mitochondrial function, and extracellular matrix biology.
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Postdoctoral FellowNational Cancer Institute (Nci) 1991 - 1993Bethesda, Md, UsStudied mechanisms of tumor cell metastasis, with emphasis on the role of tissue inhibitor of metalloproteinases on endothelial cell growth and neovascularization of solid tumors. -
Postdoctoral FellowThe Johns Hopkins Oncology Center 1990 - 1991Research focused on Ca2+-mediated signaling in tumor cells.
Anne N. Murphy, Ph.D. Skills
Anne N. Murphy, Ph.D. Education Details
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The George Washington UniversityBiochemistry And Molecular Biology
Frequently Asked Questions about Anne N. Murphy, Ph.D.
What company does Anne N. Murphy, Ph.D. work for?
Anne N. Murphy, Ph.D. works for Cytokinetics
What is Anne N. Murphy, Ph.D.'s role at the current company?
Anne N. Murphy, Ph.D.'s current role is Vice President of Biology.
What is Anne N. Murphy, Ph.D.'s email address?
Anne N. Murphy, Ph.D.'s email address is an****@****csd.edu
What is Anne N. Murphy, Ph.D.'s direct phone number?
Anne N. Murphy, Ph.D.'s direct phone number is +151043*****
What schools did Anne N. Murphy, Ph.D. attend?
Anne N. Murphy, Ph.D. attended The George Washington University.
What skills is Anne N. Murphy, Ph.D. known for?
Anne N. Murphy, Ph.D. has skills like Cell Biology, Biochemistry, Cell Culture, Life Sciences, Drug Discovery, Biotechnology, Mitochondrial Physiology, Oxidative Phosphorylation, Cell Metabolism.
Who are Anne N. Murphy, Ph.D.'s colleagues?
Anne N. Murphy, Ph.D.'s colleagues are Samantha Edell, Martha Townsend, Cara Hunt, Patrick Doherty, Anthony Richards, Raquel Sbragia Stoner, David Evans.
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