Manage and coordinate studies in GLP conditions in a leader toxicology CRO for pharmaceutical, agrochemical and chemical industries- Study plans writing, management of the in-life phase, results analysis and report writing- Coordination of the different internal and external specialists needed for the in vivo study successfull progress- Inform sponsors on-time about study events and results- AWB member

Inform research project teams about off-target and on-targets risks of compounds (oncology, neurology, metabolism):- Molecule binding profile management- Research studies monitoring- In silico Virtual Assay tool management

Cell model development for the prediction of clinical toxicity, screening of new chemical entities (oncology, cardiology, neurology, diabetis):- Preclinical protocol writing, study management (budget, timelines)- Data analysis and interpretation (cardiotoxicity, myotoxicity using phenotypic analysis, behavioural neurotoxicity on zebrafish, genotoxicity using flow cytometry), research and screening report writing.- TSA (Target Safety Assessments) analysis involvement and mitigation plan proposal- Internal and external results presentation - Technical team operational management - Litterature monitoring (cardiotoxicity, myotoxicity, cell models, in vitro methods for toxicity evaluation…)

Medico-scientific follow-up of preclinical and clinical studies in pharmacology (rheumatology, immuno-inflammation)- Translational research : link between preclinical research and clinical development (biomarker identification, clinical data interpretation)- Clinical protocol and regulatory document writing - Verification of data consistancy (raw data, statistics) and interpretation- Internal and external results presentation- Evaluation of new therapeutic target scientific relevance (auto-inflammation, auto-immunity)- Litterature monitoring (physiopathology of different rheumatologic diseases, biomarkers, immunology, inflammation, competitive intelligence...)

Management of externalized preclinical pharmacology studies (rheumatology):- Preclinical protocol writing (in vivo, in vitro), study management (budget, timelines)- Verification of data consistency (raw data, statistics), interpretation, research report writing- Internal result presentation- Litterature monitoring (osteocytes, osteoblasts, osteoclasts, bone matrix, competitive intelligence…)

PROJECT: Osteoblasts and their physico-chimical environment: matrix mineral content and micro-vibration effectsThis work showed that the bone cell extracellular matrix management towards a physiologic matrix was of first importance to understand bone cell response to mechanical stimulation (eg. osteoporosis treatment).The effect of Strontium ranelate, an anti-osteoporotic molecule was studied on osteoblasts in these physiological conditions.- Project management- Trainee management- Technical skills (cell and molecular biology, biomaterials)- International communications (posters, orlas, publications)- Litterature monitoring (osteocytes, osteoblasts, osteoclastes, cell mechanics, mechanical strains...)

SUBJECT: Mechanical strain and leptin effects on human bone tissue (ex vivo)This work showed that, cultured in a bioreactor, human bone tissue remodeling was stimulated by mechanical strains and leptin. - Oral and written national communications - Technical skills (ex vivo bone tissue culture, Zetos mechanical strain device, immuno-histo-chemistery, enzymatic assays)- Litterature monitoring (ex vivo culture, mechanical strains, osteoblasts, osteoclasts)