Anthony Vega, Phd Email & Phone Number

Dresden, Saxony, Germany

As part of the Scientific Computing Facility at MPI-CBG, I support both individual scientists in the development and execution of their image-related research projects, as well as the institute in teaching courses and developing software tools for microscopy data. My responsibilities include:- Project consultation- Image analysis software consultation- Development and application of image analysis pipelines for various tasks- Code review- Supporting the light microscopy… Show more As part of the Scientific Computing Facility at MPI-CBG, I support both individual scientists in the development and execution of their image-related research projects, as well as the institute in teaching courses and developing software tools for microscopy data. My responsibilities include:- Project consultation- Image analysis software consultation- Development and application of image analysis pipelines for various tasks- Code review- Supporting the light microscopy facility with data management and analysis- Teaching image analysis courses Show less

Dallas/Fort Worth Area

Advisors: Marc Diamond M.D and Satwik Rajaram Ph.DCenter for Alzheimer's and Neurodegenerative Diseases and Department of Bioinformatics

Advisor: Khuloud Jaqaman, PhD • Created a pipeline of image and data analysis tools applied to images of live cells and reconstituted systems to characterize the influence of the actin cortex and LAT binding partners on the mobility of LAT micro-clusters. Analysis revealed that efficient mobility of LAT clusters, during T cell activation, is dependent on a change in protein composition as clusters move through different actin architectures. • Developed colocalization software… Show more Advisor: Khuloud Jaqaman, PhD • Created a pipeline of image and data analysis tools applied to images of live cells and reconstituted systems to characterize the influence of the actin cortex and LAT binding partners on the mobility of LAT micro-clusters. Analysis revealed that efficient mobility of LAT clusters, during T cell activation, is dependent on a change in protein composition as clusters move through different actin architectures. • Developed colocalization software package, ColocP2C, designed to measure the colocalization between two imaged molecules when one displays a punctate appearance and the other displays a more continuum appearance. Applied this tool to multi-channel imaging of the receptor, CD36, and its downstream effector, Fyn. Analysis revealed that CD36 nanoclusters in F-actin-rich regions were colocalized with Fyn at all times, regardless of the presence of its ligand, TSP-1. • Developed a transient mobility analysis tool, termed “Divide-and-Conquer Moment Scaling Spectrum” (DC-MSS), designed to detect changes in molecule movement from particle tracking data. Applied this tool to single-particle tracks of the transmembrane protein CD44 on the surface of macrophages, revealing actin cortex-dependent transient mobility changes. Show less

Stanford University, Palo Alto, California

Project Title: Ovarian Cancer: Developing Better Imaging MethodsAdvisor: Edward Graves, PhD • The functional imaging approach, Positron Emission Tomography (PET), presents a powerful approach to study the biological activity of tumors in mouse models, however accumulation of PET signal in the bladder precludes analysis of proximal tumors, such as in ovarian cancer. In my second project, I worked with a group developing both imaging and image analysis protocols to quantify tumor… Show more Project Title: Ovarian Cancer: Developing Better Imaging MethodsAdvisor: Edward Graves, PhD • The functional imaging approach, Positron Emission Tomography (PET), presents a powerful approach to study the biological activity of tumors in mouse models, however accumulation of PET signal in the bladder precludes analysis of proximal tumors, such as in ovarian cancer. In my second project, I worked with a group developing both imaging and image analysis protocols to quantify tumor burden for ovarian cancer in mouse models. We were able to develop an approach that combined PET imaging with CT imaging and subsequent imaging processing to quantify both initial tumor growth and subsequent response to chemotherapy in mouse models. Show less

Houston, Texas

Project Title: Ineffectiveness of Correlation Coefficient in Determination of Image Registration AccuracyAdvisor: Thomas Guerrero, MD PhD Tracking of lung motion provides important information to minimize healthy tissue damage during radiation therapy, however accuracy metrics for tracking approaches have yielded conflicting results. In this project, I worked to identify performance metrics needed in the computational tracking of lung movement from Computed Tomography (CT) imaging… Show more Project Title: Ineffectiveness of Correlation Coefficient in Determination of Image Registration AccuracyAdvisor: Thomas Guerrero, MD PhD Tracking of lung motion provides important information to minimize healthy tissue damage during radiation therapy, however accuracy metrics for tracking approaches have yielded conflicting results. In this project, I worked to identify performance metrics needed in the computational tracking of lung movement from Computed Tomography (CT) imaging data. My work utilized image reconstruction and processing approaches to identify sources of image variation that were not captured by commonly used accuracy metrics in the field, such as the Pearson Correlation Coefficient. Show less

Doctor Of Philosophy - Phd, Molecular Biophysics

Bachelor Of Science (B.S.), Biophysics

Activities and Societies: Alpha Phi Omega