Anusha Bhat Email & Phone Number

Seattle, WA, US

Seattle, Washington, US

Seattle, Washington, US

• Leading downstream development to create highly purified rAAV viral vector
• Spearheading purification of rAAV from cell culture using state-of-the-art viral vector manufacturing technologies
• Executing small-scale screening activities, lab scale material generation for development studies
• Generating new ideas for downstream tech dev initiatives and proposals for future projects

Wuxi, Jiangsu, CN

• Served as a scientific team member for advanced drug substance purification for defined biopharma projects
• Developed and characterized robust clinical processes for efficient, scalable, and cost-effective downstream purification process
• Performed downstream purification (TFF) of non-infectious biological material of bacterial origin
• Led process improvement initiative for TFF filter reuse studies
• Applied statistical and data analysis (JMP) to support new product introduction and to improve existing processes

Lawrence Township, NJ, US

• Worked on a project to understand the cause to form product-related impurities throughout the manufacturing process for a mAb-derived molecule and ultimately to develop a controlling strategy to minimize the impurity.
• Generated impure species of the molecule through tandem SEC separation and design studies to confirm the hypothesis of the formation mechanism
• Designed cell culture conditions to create various levels of the impurities to study factors regulating disulfide bond reduction and free thiol group formation

Tarrytown, New York, US

• Involved with clinical and commercial purification process development
• Utilized NanoDSF to study (DOE) protein unfolding and aggregation on chromatographic resin
• Used a predictive statistical model (JMP) for high throughput screening model performance
• Carried out daily lab operations and made buffers to support all steps of the purification process

New Brunswick, New Jersey, US

• Worked on “Mechanistic Understanding of Hydrophobicity on Bi-Component High Shear Wet Granulation Growth”
• Contributed to the development of a model that can predict granule product attributes based on individual raw materials
• Compared the simulated model (PBM) with experimental results to confirm the validity of the aggregation kernel

New Brunswick, New Jersey, US

• Taught Introduction of Chemistry Lab (171) for a class of junior year chemical engineering students

Midland, Michigan, US

• Implemented Process Design Fundamentals w.r.t safety and over-pressure scenario identification of related unit operations w.r.t API-14C and Involved in the purchasing, installation, and documentation of Pressure Safety.
• Calculated pressure relief designs using Aspen Plus and Flowmaster and being in accordance with ASME methodology
• Process Optimization and Troubleshooting of processes and equipment

• Calculated downtime, pace time and Overall Equipment Effectiveness (OEE) for analyzing the present state
• Implemented 5S and visual management on the production floor

Mumbai, IN

• Oriented in studying P&IDs, equipment specifications, data sheets, and utility requirements from conceptual design
• Extensively worked on the design of Heat Transfer and Drying Equipment using Aspen Plus

IN

San Ramon, CA, US

Master Of Science - Ms, Chemical Engineering

Bachelor Of Technology (B.Tech.), Chemical Engineering