Arindam Basu, Phd, Dipwset Email & Phone Number

King Of Prussia, Pennsylvania, United States

• Overseeing lab activities and assays execution of junior members of the team and mentoring them.
• Execution of testing in development laboratory.
• Collaborate with a diverse team to execute assays for cell and gene therapy applications.
• Design and conduct cell-based and molecular assays for gene & cell therapy products.
• Generate, analyze, and record data using electronic documentation, and database tools.
• Maintain laboratory records and contribute to laboratory organization and maintenance.

Philadelphia, Pennsylvania, United States

• Demonstrated a thorough understanding of GxP and regulatory guidelines and requirements for GLP and IND studies in collaboration with sponsors.
• Led development and qualification of GC titer assays using Poly A targets, analysis of biodistribution of viral vectors in rodents and non-human primates (NHP).
• Oversaw testing under research and GLP/GMP environments with QA oversight. Interacted with three internal and external sponsors and CDMOs for procurement of source material and testing. Coordinated extensively with.
• Developed robust training programs for 5 operators and ensured proper documentation and lab workflow following GxP guidelines.
• Participated in implementation of new methods and establishment of automation technology (Hamilton) that is currently being qualified for GLP testing.
• Instrumental in authoring and reviewing technical reports, SOPs, test / batch records, qualification reports and relevant sections of regulatory submissions.

Philadelphia, Pennsylvania, United States

• Provided training and guidance to four associate scientists and several technicians across five “buckets”.
• Oversaw assay / method development and optimization of reference standards for increased testing efficiencies.
• Ensured initiation and completion of non-compliance items such as laboratory investigation, NCE, CAPA in conjunction with client requirements.
• Provided scientific expertise to other “buckets” such as residual, genomic stability, sequencing.
• Oversaw preparation of technical documents (CoA, CoT, R&D reports, VP, QP reports) and performance of testing in accordance with company SOPs, GxPs, ICH and 21 CFR Part 11.

Philadelphia, Pennsylvania, United States

• Conducted and directed assays and lab procedures in compliance with cGMP, CFR and SOPs.
• Provided accurate completion of batch records and required documentation in adherence with SOPs.
• As Technical Reviewer, demonstrated scientific expertise to conduct critical review of results and data reporting as well as initiated, prepared and revised technical documents, and SOPs.
• Provided training to new personnel on issues relevant to the lab operations.
• Interacted with clients to address scientific and technical issues as well as non-compliance documents.
• Contributed to overall departmental goals by performing job specific tasks in compliance with regulatory guidelines, international standards, SOPs, and WuXi AppTec policies.

Media, Pennsylvania

• Taught undergraduate courses including Human Anatomy & Physiology, Introductory Biology (writing course), Bioinformatics, as well as the labs associated with these courses.
• Explained complex concepts in a clear, easily understood manner and provided students with hands-on learning opportunities.
• Participated in lab meetings (with undergraduate research students), seminars, and committees to share information regarding best practices in research.
• Supervised undergraduate student-driven research focused on genome wide binding of transcription factors, Polycomb proteins, and chromatin modulators.
• Guided students in writing accurate, articulate articles presenting their research findings; instructed on how to maintain detailed records on experimental setup and follow good GLP practices; empowered students to.
• Engaged in scientific writing leading to multiple publications as well as regional and international presentations.

Philadelphia, Pennsylvania

• Performed experiments focused on B-cell biology and Polycomb proteins.
• Explored DNA-protein interactions using ChIP-seq, 3C assays, CoIP, EMSA, yeast two-hybrid and other techniques.
• Was involved in antibody generation, transduction of splenic B cells and bone marrow cells with retro viral vectors for overexpression of proteins for downstream biochemical assays.
• Led student-driven research projects as part of their undergraduate degree.
• Collaborated with faculty, post-docs, and students on projects.

Philadelphia, Pennsylvania

• Initiated and established ChIP-seq, RNA-seq, and microarray protocols resulting in publications.
• Established PCR-based immunoglobulin gene rearrangement assays in pro- and pre-B cells.
• Orchestrated pioneering work in epigenetics involving Polycomb recruitment to DNA by using ChIP, co-IP, and yeast two-hybrid methods leading to 4 publications.
• Initiated studies with small peptides for use as therapeutic target in cancer cell lines.
• Established SELEX studies to determine novel DNA binding sequence of transcription factors.
• Generated and established transgenic Drosophila lines for genetic and biochemical assays.

Doctor Of Philosophy - Phd, Biochemistry And Molecular Biology (Gene Regulation)

Thesis: Insights into Transcriptional Regulation of the receptor Guanylyl Cyclase C gene: Role of HNF4, COUP-TFs, and GATA-6 transcription.

Master Of Science - Ms, Biotechnology

Dissertation: Decolorization of textile mill effluents using the fungus, Aspergillus foetidus.

Bachelor Of Science - B.Sc., Human Physiology

Level 4: Diploma In Wines

Certified Specialist Of Wine

Level 1 Sake, Wine Steward/Sommelier

Certified Sherry Wine Scholar (Csws), Wine Steward/Sommelier, Highest Honors