Dr. Arjun Sharma, Phd, Mba Email and Phone Number
Publications: 18+ (6 as First Author; 12 as Co-Author; & 4 Manuscripts in process).Immigration Status: United States Permanent Resident (Green Card).My work is contributing to a better understanding of the molecular pathogenesis of sepsis and lung injury (including COVID-19), thereby helping to identify new avenues for therapeutic interventions.My research includes Inflammation, Host-Pathogen interaction, Pulmonary disorders (including SARS-CoV-2 infection which causes COVID-19 disease), and their connections to innate immunity with a background in Immunology, Internal medicine, Hematology-Oncology, Genomics, Proteomics, Cellular, and Molecular Biology.HANDS ON TECHNIQUES:Cell and Tissue Culture-Culture and maintenance of cell lines; Isolation-culture and stimulation of Macrophages/Neutrophils/Mast cells/Platelets/Megakaryocytes; CFUs and bacterial culture; Cell proliferation assays; Soft-Agar assay; MTT assay; Competent cell preparation; shRNA-siRNA cloning and transfection; Viral production and infection; Apoptosis assay; Cell cycle assay; Flow cytometry; Cytek Aurora Spectral Flow Cytometry; Fluorescence Activated Cell Sorting (FACS); Prime flow RNA assay; Immunohistochemistry, Immunofluorescence imaging; Vectra polaris imaging system, IVIS spectrum fluorescence imaging; Laser speckle contrast imaging.Molecular Biology and Biochemistry- CRISPR technology; Next generation sequencing; Single-cell RNA sequencing; DNA sequencing; Sanger sequencing analysis; Reverse Transcription PCR; Quantitative Real-Time PCR; Western blotting; Image J software; Genomic DNA/RNA/Plasmid isolation; Primer designing; SNP-Chip analysis; Microarray analysis; Multiplex-Bioplex analysis; ELISA; Co-Immunoprecipitation; Isothermal titration calorimetry.Animal work-Animal surgery and organ isolation (mice, rat, and zebrafish); FELASA B certificate; RCULA course certificate from the National University of Singapore; Generation of transgenic mice using CRISPR; Bone marrow transplantation; Sepsis models; Lung-fibrosis models; Influenza models; intravenous injections; Retro-orbital injections; Intratracheal injection; Isolation of peritoneal and broncho-alveolar lavage fluid; Murine hookworm (Nippostrongylus brasiliensis) models.Programming language- R; PythonScientific Expertise: Sepsis; Pulmonary disorders & Lung Injury; COVID-19 disease; Immunology; Cellular & Molecular Biology; Internal Medicine; Hematology-Oncology. Managerial Expertise: Operations; Innovations; Digital Health; Service Delivery; Strategy & Execution; Negotiations; Project Management.
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Harvard UniversityBoston, Massachusetts, United States -
Research FellowBoston University School Of Medicine 2018 - PresentBoston, Ma, Us-Publications: 18+ (6 as First Author, 12 as Co-Author; & 4 Manuscripts in process).-Investigating the cellular and molecular mechanisms during the development and progression of sepsis to provide a helpful basis for designing better treatment approaches for sepsis patients in the future.-Investigating on pulmonary disorders and their connections to innate immunity, host-pathogen interactions, and inflammation.-Member of Affinity Research Collaboration (ARC) “Respiratory Viruses: A Focus on COVID-19”.I am establishing robust cell culture models for SARS-CoV-2 infection, the virus causing COVID-19 disease. I also design assays to utilize and analyze human inducible pluripotent derived airways epithelial cells for COVID-19 research.-Investigating the role of pro-inflammatory such as IL-27 in γδ T cell-mediated innate resistance to primary hookworm infection in the lungs, which is an interesting factor to explore for developing adjuvants for vaccines that target the lung stage of human hookworms.-Investigating the role of extracellular histones during pulmonary fibrosis in the focus of the search for future treatment options for pulmonary fibrosis.-Lab manager and performs various duties, including laboratory organization (IACUC, IRB, IBC protocols, mouse colony supervision), assistance with scientific writing of manuscripts & grants and mentoring of trainees (Ph.D. students, undergraduates, and lab technician). -
Doctor Of Philosophy - Phd, Translational MedicineJohannes Gutenberg University Mainz 2016 - 2024Mainz, Rheinland-Pfalz, DePh.D. Thesis entitled “Immunity in the Context of Pathogens: Elucidating the Complexity of Host Defense Response Mechanisms”. Grade: “Magna cum laude (High Honor Award)".The thesis identifies the molecular mechanisms of host-pathogen interactions and infection-associated inflammation, and suggests potential targets for immunotherapy. -
Graduate Research AssociateJohannes Gutenberg University Mainz 2014 - 2016Mainz, Rheinland-Pfalz, DeParticipated in independent and several ongoing projects which are published in BBRC journal and Immunobiology journal.-My study revealed that the neuroendocrine influences of the Hypothalamic-Pituitary-Adrenal (HPA) axis on the shock-associated inflammatory response are more selective and complex than previously known. These findings will be helpful to predict some of the consequences of therapeutic manipulations of the HPA in the context of sepsis and septic shock. -My study highlighted the negative contribution of NETs release in fungal infection in a vulnerable organ such as the lung. Inhibition of NETs formation might therefore be a useful strategy to avoid lung damage in immunocompromised patients, especially in those suffering from preexisting pulmonary disease.
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Research AssistantNational University Of Singapore Jun 2012 - Dec 2014Singapore, SgParticipated in several ongoing projects which are published in Nature Genetics journal, PNAS journal, and Nature Oncogene Journal. Trained in most of the cellular and molecular biology techniques such as cell culture, animal handling, molecular cloning, in-vitro assays, Sanger sequencing, bioinformatics analysis, western blotting, FACS analysis, transfection and transduction using lentivirus. -
Master'S Dissertation ResearchNational University Of Singapore Dec 2011 - Jun 2012Singapore, SgMy Master's research dissertation entitled “Protein Tyrosine Phosphatase Receptortype Delta (PTPRD): A Potential Tumor Suppressor” under the guidance of Prof. H. Phillip Koeffler M.D. Senior Principal Investigator, CSI Singapore; Professor of Medicine, NUS and Cedars-Sinai Medical Center, University of California, Los AngelesThis research study identified PTPRD as a tumor suppressor that is involved in the development of Triple-negative breast cancer, Gliomas, and multiple human cancers. The work involved transfection, virus production, lentiviral infection, apoptosis assay, MTT assay, soft-agar assay, FACS, Polymerase Chain Reaction, Reverse Transcription PCR, Quantitative Real-Time PCR, DNA sequencing, and Western Blotting.
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Research And Development InternDalash Biotech Pvt. Ltd. Bhiwadi, India Jan 2009 - Jun 2009Gained hands-on experience in Quality Control and Production Laboratory operations, specializing in the production and analysis of Penicillin G Acylase enzyme.
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Research InternCentral Bureau Of Investigation. Jun 2008 - Jul 2008Completed specialized training in DNA Profiling, Forensic Serology, and Forensic Biology at the Central Forensic Science Laboratory (CFSL), Central Bureau of Investigation (CBI), Government of India, New Delhi.Gained hands-on experience in advanced forensic technologies and methodologies. -
Research InternSaras Jaipur Dairy Jun 2007 - Jul 2007Jaipur, Rajasthan, InCompleted training in Quality Control and Production processes for milk and various dairy products at Government Saras Dairy, Jaipur, India. Acquired practical experience in maintaining product standards, ensuring quality, and optimizing production workflows.
Dr. Arjun Sharma, Phd, Mba Education Details
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Johannes Gutenberg University MainzTranslational Medicine -
Questrom School Of Business, Boston University& Innovations
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Boston University College Of EngineeringProgram & Project Portfolio Management
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Boston University - Frederick S. Pardee School Of Global Studies (Pardee School)International Relations And Global Security
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Vellore Institute Of Technology (Vit)Biotechnology
Frequently Asked Questions about Dr. Arjun Sharma, Phd, Mba
What company does Dr. Arjun Sharma, Phd, Mba work for?
Dr. Arjun Sharma, Phd, Mba works for Harvard University
What is Dr. Arjun Sharma, Phd, Mba's role at the current company?
Dr. Arjun Sharma, Phd, Mba's current role is Boston University School of Medicine.
What schools did Dr. Arjun Sharma, Phd, Mba attend?
Dr. Arjun Sharma, Phd, Mba attended Johannes Gutenberg University Mainz, Questrom School Of Business, Boston University, Boston University College Of Engineering, Boston University - Frederick S. Pardee School Of Global Studies (Pardee School), Vellore Institute Of Technology (Vit).
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