Arlan Ashby, Md Email and Phone Number
Urogynecologic Surgeon/Women’s Health Specialist with 20 years of patient care and research experience.I am currently Principal Investigator at Metamol Theranostics. Metamol's mission is to develop a highly specific diagnostic and therapeutic strategy to fight the spread of cancer. MetaMol‘s commitment to the development of anti-metastasis drugs is derived from studies of osteopontin, a glycoprotein that is normally secreted by cells of the immune system. Osteopontin has also been associated with metastasis formation by various cancers. Specifically, we have demonstrated that the shortest splice form of osteopontin, “osteopontin-C”, is exclusively present in 75-80% of breast cancers, while not even a trace is detectable in normal breasts. Further, osteopontin-C plays an important role in conveying aggressive behavior to breast cancer cells, as it strongly supports anchorage-independence. Without anchorage-independence, disseminating cancer cells could not survive in the circulation.Therefore, improved protection from metastasis and relapse will hinge on agents that directly suppress the molecules that mediate cancer invasiveness and anchorage-independence, the two basic mechanisms of metastasis. MetaMol’s mission is to develop diagnostics for the ability of cancer to spread and to supplement existing cancer therapies with anti-metastasis drugs.
Metamol Diagnostics
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Principal InvestigatorMetamol Diagnostics Jan 2024 - Present- Responsible for the preparation, conduct, and administration of research grants, cooperative agreements, training in compliance with applicable laws and regulations and institutional policy governing the conduct of sponsored research.- Graduated from NSF Sponsored I-Corp program at University of Akron/University of Toledo - Fall 2024- Conducted in-depth market research to identify problems within industry protocols, potential customers, and market trends. - Developed and refined a problem-solution fit of a new technology within the market and compared the innovation to competitive solutions. - Collaborated with teams to iterate product/service requirements based on valuable customer feedback and generated unique value propositions. - Pitched a business idea and provided meaningful updates to peers and program advisors, honing communication and presentation skills.
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Drug Safety Associate, TraineeMedipharmsolutions Dec 2022 - Mar 2023Somerset, Nj, Us- Processed Adverse Event cases from end-to-end, which included reviewing, triaging, and processing of Individual Case Safety Reports (ICSR's) using ARGUS.- Conducted medical reviews of clinical trial cases, prioritized them, and determined regulatory reporting requirements.- Coded adverse events and medications using MedDRA and WHO-DD.- Composed narrative summaries and performed medical assessment of adverse events.- Conducted medical reviews of Individual Case Safety Reports (ICSR's), coded them, and determined the expectedness/listedness of Adverse events in reference safety documents such as IB, CCDS, SmPC, USPI.- Ensured that cases were reported to regulatory authorities and business partners in a timely manner.- Reviewed narratives for medical coherence and provided comments as per company requirements.- Identified and reviewed SUSAR cases. -
Medical Director, UrogynecologyKettering Health Feb 2009 - Jul 2022Kettering, Oh, Us- Served as founding member and medical director for a Urogynecological subspecialty surgery practice- Led growth of practice to a four provider team, with an office staff of 12 people - Oversaw strategic planning, budget, staffing and conflict resolution for a busy medical practice billing over $2.5M annually- Established a patient focused, team-oriented office and hospital culture which supported a high volume medical practice, personally averaging 2000 office visits and over 250 surgeries annually- Created a supportive work environment where only 1 office staff member left for reasons other than professional/academic advancement or retirement over 13 years -
Core Clinical Faculty Member, Ob/Gyn Residency ProgramKettering Health Feb 2009 - Jul 2022Kettering, Oh, Us- Provided academic mentorship and education to OB/GYN residents in both the in-patient and out-patient settings, graduating 39 residents over my 13 year tenure- Taught surgical skills in both the operating room and cadaver lab settings-Developed basic surgical skills lecture series and labs focusing on understanding instrument nomenclature, handling and uses of gynecologic surgical instruments and proficiency in basic suturing techniques- Directed annual hands-on training session using a beef-tongue model to teach obstetric injury repair- Received Golden Apple Teaching Award, as Best Faculty Educator in 2021
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Medical DirectorKettering Health Network Feb 2009 - Jul 2022
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Post-Doctoral Research Fellow, Ob/Gyn And Biomedical EngineeringCleveland Clinic Jul 2007 - Jan 2009Cleveland, Ohio, Us- Developed novel surgical and data collection techniques to validate a model of urogenital prolapse in genetically modified mice. Studies performed to validate this model were used to apply for a grant investigating the use of Mesenchymal Stem Cells to prevent urogenital prolapse after childbirth injury (see below)- Published peer-reviewed articles in academic journals including, American J Physiology, Neurourology and Urodynamics, Female Pelvic Medicine and Reconstructive Surgery- Awarded Research Supplement to National Institutes of Health (NIH) R01 Grant to Promote Diversity in Health-Related Research- Led multidisciplinary team to develop a research plan investigating the role of elastin in female pelvic floor dysfunction using mesenchymal stem cells in LOXL-1 KO mice- Granted U.S. Department of Veterans’ Affairs Career Development Award: Stem Cell Homing and Elastin in Female Pelvic Floor Dysfunction -
Clinical Fellow, Female Pelvic Medicine And Reconstructive Surgery (Urogynecology)Cleveland Clinic Jul 2004 - Jun 2007Cleveland, Ohio, Us- Designed, executed, published and presented retrospective chart reviews, anatomic cadaver studies, and surgical education videos which contributed to the understanding of complications associated with female pelvic floor surgery- Performed basic science research in small animal subjects, with an emphasis on understanding the role of elastin in female pelvic floor dysfunction in a genetically modified mouse model- Published peer-reviewed articles in academic journals including, American Journal of Obstetrics and Gynecology, International Urogynecology Journal, Journal of Minimally Invasive Gynecology- Presented jury-reviewed oral and poster presentations at academic medical conferences, including American Urogynecological Society, International Urogynecological Society, American Urological Association, and Society for Urodynamics and Female Urology
Arlan Ashby, Md Education Details
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Yale UniversityBiology -
Mayo Clinic Alix School Of MedicineMedicine
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Duke UniversityObstetrics And Gynecology Residency Program
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Certified Clinical Research Professionals Society (Ccrps)Certification
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Certified Clinical Research Professionals SocietyAdvanced Clinical Research Associate Certification
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Cleveland Clinic Lerner College Of Medicine
Frequently Asked Questions about Arlan Ashby, Md
What company does Arlan Ashby, Md work for?
Arlan Ashby, Md works for Metamol Diagnostics
What is Arlan Ashby, Md's role at the current company?
Arlan Ashby, Md's current role is Medical Doctor/Urogynecologic Surgeon/Women's Health Specialist/Principal Investigator.
What schools did Arlan Ashby, Md attend?
Arlan Ashby, Md attended Yale University, Mayo Clinic Alix School Of Medicine, Duke University, Certified Clinical Research Professionals Society (Ccrps), Certified Clinical Research Professionals Society, Cleveland Clinic Lerner College Of Medicine.
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