Arnab Mukherjee Email and Phone Number
Arnab Mukherjee work email
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Arnab Mukherjee personal email
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I am a passionate and goal-oriented biochemical scientist with over 15 years of working experience in biophysical characterization, protein-ligand interaction, enzymology, bioanalytical chemistry, protein structure-activity relationship, computational biology, and in-vitro assay development. Highlight of technical skills: 1) Extensive experience in biophysical characterization using spectroscopy techniques (UV-Vis, fluorescence, MS, electrophoresis)2) Expert in protein purification using various chromatography techniques (FPLC, affinity, ion-exchange, IEX, SEC etc)3) Adept in analytical method development (RP-HPLC, LC-MS/MS, GC-MS) for separation and quantification of small and macromolecules.4) Troubleshooting experience in enzymatic assay development (O2 electrode, QqQ ESI-MS/MS, fluorescence, radioactive assay ([125I] iodide), UV-Vis).5) Extensive experience with molecular biology techniques used in recombinant protein expression (cloning, PCR, SDM, transformation etc). 6) Computational biology tools - Homology modeling, MD simulation, protein-protein/small molecule docking, epitope mapping, compound similarity search, in-silico screening of small molecules libraries, protein residue scanning for affinity maturation, protein/ligand interaction fingerprint. When I am not in the laboratory, I love hiking in the mountains, watching thriller and comedy movies, running, spending time with friends and family, and learning about human psychology. You can reach me here at its.arni@gmail.com or 2178988732
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Corellia Ai
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Principal ScientistSensei Bio Mar 2023 - PresentRockville, Maryland, Us• Led protein science department at Sensei Bio for over three and half years. • Supervised the protein production from various sources (mammalian, bacterial).• Introduced several chromatography protocols to obtain highly purified, endotoxin free proteinsuitable for in vivo studies. • Spearheaded the characterization of over 100 proteins with UPLC-SEC, capillary gel electrophoresis. • Led the SPR characterization of interaction between receptor/antigen, antigen/lead mAb candidate for 4 pipeline projects. Established the 3 lead candidates for pipeline target molecules.• Implemented computational biology (Schrodinger Biologics) techniques to predict the epitope for three pipeline mAb candidates.• Established the epitope for three pipeline drug candidates using a combination of computational (docking, fingerprint interaction search) and experimental (point mutation, SPR) techniques.• Introduced an interdisciplinary (computational, structural, and experimental) approach to design a low pH selective antibody from a pH non-selective antibody for a specific target.• Steered collaborations to obtain the experimental structure of two antigen: Fab (lead candidate) complex. Analyzed x-ray crystallography and cryo-EM data to establish the interaction.• Demonstrated managerial role by mentoring and guiding two research associates. -
Senior Scientist, PreclinicalSensei Bio Apr 2021 - Mar 2023Rockville, Maryland, Us
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Research SpecialistHoward Hughes Medical Institute Jul 2016 - Apr 2021Chevy Chase, Maryland, Us• Implemented and optimized molecular biology and chromatography techniques in introducing unnatural amino acid in bacterial protein cfr to understand the mechanistic details of its role in antibiotic resistance. • Independently designed and spearheaded computer-aided drug discovery (CADD) research in the laboratory including handling big database, virtual screening of small molecules, fingerprint similarity search that identified several potential lead molecules for preliminary biochemical assay and synthesizing new compounds. • Developed and refined biochemical assays to accelerate screening of potential inhibitors generated from computational studies. -
Postdoctoral Research FellowJohns Hopkins University Aug 2012 - Oct 2015Baltimore, Md, UsUnderstanding the evolutionary relationship of mammalian enzyme Iodotyrosine Deiodinase (IYD) with bacterial protein Nitroreductases (NR).a)Successfully identified the key catalytic residues in IYD and NR using molecular visualization software and converted IYD to NR through minimum mutations.b) Single handedly established highly specialized conditions to characterize and purify the product of nitroreductase activity using HPLC and multiple spectroscopies.Identification of in vivo reductase of mammalian IYD.a)Predicted reductase gene in IYD homologue containing bacteria using bioinformatics databases and cloned the winner genes in E. coli to over express reductase proteins using recombinant protein expression technique. -
Postdoctoral Research FellowUniversity Of Illinois At Urbana-Champaign Nov 2009 - Jul 2012Champaign, Il, UsEngineered myoglobin from normal O2 binding protein to O2 reducing and O-O bond formation enzyme.a) Developed assays to identify the product of O2 reduction i.e. water.b) Proposed the role of different mutations in novel O2 reduction activity of myoglobin. Developed multiple mass spectroscopy and separation methods (HPLC) to detect a novel His-Tyr crosslink in myoglobin -
Graduate StudentJohns Hopkins University Jan 2005 - Jan 2010Baltimore, Md, Us• Investigated mechanisms of three different enzymes that use O2 as a substrate: Cyclooxygenase, copper amine oxidase and rice alpha oxygenase.• Standardized various techniques like pH studies, viscosity studies, competitive isotope effects, stopped-flow kinetics towards development of novel mechanistic probes.
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StudentIndian Institute Of Technology, Bombay Jun 2001 - Dec 2004Mumbai, Maharashtra, Ina) Investigated the effect of various osmolytes (TMAO, betaine) on the stabilization of protein against various denaturing reagent using light scattering technique, fluorescence, CD, UV-visible spectroscopy, sedimentation assayb) Synthesized successfully a novel organoselenium compounds containing sulfur di-6-[(phenylthio)methyl]phenyl diselenide and established the intramolecular Se..S interaction by various spectroscopic methods like NMR (1H, 13C, 77Se), IR, Mass spectroscopy
Arnab Mukherjee Skills
Arnab Mukherjee Education Details
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The Johns Hopkins UniversityChemistry -
Indian Institute Of Technology, BombayChemistry
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Jadavpur UniversityChemistry
Frequently Asked Questions about Arnab Mukherjee
What company does Arnab Mukherjee work for?
Arnab Mukherjee works for Corellia Ai
What is Arnab Mukherjee's role at the current company?
Arnab Mukherjee's current role is Principal Scientist, Preclinical at Sensei Bio.
What is Arnab Mukherjee's email address?
Arnab Mukherjee's email address is it****@****ail.com
What schools did Arnab Mukherjee attend?
Arnab Mukherjee attended The Johns Hopkins University, Indian Institute Of Technology, Bombay, Jadavpur University.
What are some of Arnab Mukherjee's interests?
Arnab Mukherjee has interest in Science And Technology, Social Services, Education, Arts And Culture.
What skills is Arnab Mukherjee known for?
Arnab Mukherjee has skills like Spectroscopy, Mass Spectrometry, Nmr, Uv/vis, Protein Chemistry, Protein Purification, Chemistry, Protein Expression, Biochemistry, Fluorescence, Inorganic Chemistry, Pcr.
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