Arnold Van Loevezijn Email & Phone Number

Utrecht, Netherlands

The Medicines Evaluation Board (College ter Beoordeling van Geneesmiddelen) has key responsibilities in assessing, authorizing and monitoring medicinal products for human use in The Netherlands and the EU. Within the agency supporting the board, I am involved in the assessment of the chemical and pharmaceutical quality parts of marketing authorization applications for innovative and generic medicinal products.

Amsterdam, North Holland, Netherlands

Albemarle's Catalysts business is now Ketjen, a wholly owned subsidiary.

Amsterdam, North Holland, Netherlands

Key responsibilities:• Leading exploratory research projects with inclusion of high throughput preparation and testing protocols. Supporting role in development of transferred leads.• Specialist role with leading strategic input in R&D team working on an optimized commercial route for a high-performance specialty product; development ongoing.Main achievements:• Project driven by personal expertise enabled the launch of a new product on the market. Patent application(s) in preparation.• Received 4 internal Technology Awards for breakthroughs in discovery/R&D projects.Other roles:2020 - 2023: Member of the Works Council, member of its Personnel & Organization committee and chair of its Safety, Health & Environmental committee.

Amsterdam Area, Netherlands

Key responsibilities:• Development and application of methods for high throughput characterization and screening of catalyst materials for the oil and waste stream refinery industry.• Liaison between Analytical Research and other departments, supporting a broad range of projects and safety studies from early phase research to production trials.Main achievements:• Co-inventor on 2 granted patents for commercialized catalytical products/processes.• Development of an in-line analytical monitoring method to enable a safe production trial of a new product.• Received 4 internal Technical and Innovation Awards and a 2016 US Presidential Green Chemistry Challenge Award for key roles in various team efforts.Other roles:2012 - 2019: Key team member delivering preparative and mechanistic knowledge in a joint development program with ExxonMobil for development and commercialization of a new generation of a specialty hydroprocessing catalyst.2013 - 2015: Key team member delivering analytical and mechanistic knowledge to enable successful scale-up of the world’s first commercial solid acid alkylation catalyst.

Weesp, North Holland, Netherlands

In February 2010, Solvay Pharmaceuticals was acquired by Abbott.

Weesp, North Holland, Netherlands

Key responsibilities:• Delivering drug development candidates by managing research stages from target finding, via flowscheme definition and realization, hit finding and hit-to-lead, to lead optimization. Responsibility for milestones and patenting strategy.• Central role in interdisciplinary program team, bringing results from in vitro and in vivo pharmacology and ADMET, molecular modeling, physicochemical analyses and target-ligand interaction studies back to molecular properties, and translate them into design and synthesis of optimized generations of “druglike” compounds.• Guidance of a team of synthetic-organic chemists.• Primarily responsible for Lead Optimization activities around a GPCR target related to cognitive dysfunction.Main achievements: • Delivery of 2 preclinical candidates from a unique structural class with added selectivity and safety value over known competitor compounds, of which 1 made it to Phase II clinical trials.• Co-inventor on 4 granted patents. Main author on 2 medicinal chemistry publications, co-author on 1 synthetic and 3 pharmacological publications.Other roles:2009 - 2010: Research Team Representative (Alzheimer’s Team)• Medicinal Chemistry representative in an interdisciplinary Research Team, coordinating, planning and budgeting internal and external research on all Alzheimer’s targets in the global organization.• Proposal of new targets, development of target validation plans, design of flow schemes and communication with external partners/ collaborators.2007 - 2008: Coordinator international chemistry outsourcing• Coordination and support of organic synthesis programs outsourced to a CRO abroad. • Monitoring and steering of progress by regular teleconferences and visits.

Weesp, North Holland, Netherlands

Key responsibilities:• Integration of solid phase synthesis into an existing automated parallel synthesis platform.• Implementation of use of scavenger resins and solid-supported reagents in parallel solution phase synthesis protocols.• Collaboration with IT and technological partners to upgrade synthesis robot functionalities.• Development of multistep solid phase synthesis routes towards new core structures.Main achievements:• Automation of parallel solid phase synthesis enabling compound libraries with multidimensional structural diversity.• Training of new colleagues in solid phase synthesis and parallel purification protocols employing scavenger resins and solid phase extraction.• Co-author on 1 publication resulting from an academic collaboration.

Amsterdam, North Holland, Netherlands

First academic combinatorial chemistry project in the Netherlands, financed by NWO-CW/STW: joint program from Universities of Utrecht, Amsterdam and Nijmegen and Solvay Pharmaceuticals.• Development of methodologies for synthesis of indole alkaloid derivatives on solid support with smart intrinsic purification, and validation by compound library synthesis.• In collaboration with the Netherlands Cancer Institute (NKI, Division of Experimental Therapy): screening of libraries for inhibition of a multidrug efflux pump causing chemotherapy resistance, followed by hit deconvolution and lead optimization.Main achievements:• 4 scientific papers in peer reviewed journals, of which one has >600 citations.• Optimized lead compound has become the tool of choice for selective inhibition of the target and is now commercially available.• Thesis has been awarded with the 2003 Andreas Bonn Medal of the Dutch “Genootschap ter Bevordering van Natuur-, Genees- en Heelkunde”.

Phd, Bio-Organic Chemistry, Phd

First academic combinatorial chemistry project in the Netherlands, financed by NWO-CW/STW: joint program from Universities of Utrecht.

Msc, Chemistry, Msc

Master’s research project, University of Amsterdam, department of Bio-Organic Chemistry (1994-1995): Design, synthesis and biological.

Highschool Diploma, Vwo

Activities and Societies: Student member of the Participation Coincil. Member of the Student’s Council. Editor of the school's magazine..