Arpit Doshi, Ph.D. Email & Phone Number

Mountain View, California, United States

-Work with biologists to advance drug discovery pipeline.-Act as a liaison between outside contractors working on synthesis of large scale preclinical candidate of the company and the company-Lead medicinal chemistry team efforts (including internal and external members), prioritize targets for synthesis and further profiling.-Design novel small molecules across multiple projects which address key issues faced by the project teams.-Utilize scientific literature and databases to design and implement efficient synthetic routes.-Clearly analyze, troubleshoot, accurately document, and communicate experimental results.-Maintain a high level of scientific integrity, laboratory safety and act as a resource for others.-Collaborate and communicate across a diverse research team to successfully progress time-sensitive scientific goals.

Mississauga, Ontario, Canada

- Developed process technology for production of active pharmaceutical ingredients-Led a project involving a small scale synthetic route for development of an impurity observed during formulation formation for an ophthalmic drug, delivered ~150 g of the impurity, specially focused on lowering levels of DCM below ICH limits- Proposed and identified efficient and scalable synthetic routes for development of APIs-Developed keen knowledge of developing scalable synthetic routes by understanding the equipments and technologies available in the pilot plant, focusing of developing synthetic routes that allowed smooth technology transfer to the pilot plant-Interpreted analytical data of experiments to drive synthetic experimental plans and quickly resolve key bottlenecks in the process-Collaborated successfully with solid state research department within the company to develop synthetic routes to obtain pure polymorph form of the API. The process was successfully transferred to Pilot plant to obtain multi-kilogram quantities of the APIs-Helped deliver multi kilogram quantity of API for IND enabling studies-Leveraged technologies, such as HPLC, UPLC, MS, NMR, and IR to identify the impurities formed during a particular process and modify the process to bring the levels of each impurities within the specifications-Used solid-state technologies, such as PLM and FBRM probe to monitor novel purification and crystallization processes to identify different polymorphs of product formed in the process and design experiments to obtain desired polymorph of the product in higher yields-Recorded experimental procedures meticulously in lab notebook-Communicated results of experiments and path forward for different projects to internal and external stakeholders weekly- Presented progress of the project to both internal and external stakeholders- Prepared lab reports for final synthetic processes for the API

United States

- Identified and resolved key bottlenecks in synthetic scheme to obtain a preclinical candidate in multigram quantities- Synthesized diverse series of NOP receptor ligands, such as N-(heteroalkyl)-piperidin-4-yl-1H-indole II 1'-(4-heteroalkyl)-1,2-dihydro-3H-spiro[isoquinoline-4,4'-piperidin]-3-one II 4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decanone II N-(heteroalkyl)piperidin-4-yl-2-oxoindoline- Purified multigram quantities of diastereomeric mixtures using a quaternary blend of solvents by column chromatography - Developed computational methods to rationalize the structure activity relationship of the compounds designed and synthesized in-house to obtain desired pharmacological profile

Pittsburgh, Pennsylvania

- Carried out benchtop, moisture-sensitive, and microwave assisted organic synthesis- Purified compounds using conventional and Combiflash Rf, High performance liquid chromatography (HPLC), prep TLC- Synthesized >30 heterocyclic compounds such as quinazolines, pyrido[2,3-d]pyrimidines, pyrido[3,2- d]pyrimidines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, pyrimido[4,5-b]indoles, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as anti-cancer and anti-opportunistic agents- Computational studies performed using MOE, Sybyl-X Suite, LeadIT, Discovery Studio, and Schrödinger at various targets for publications, presentations and research grants- Characterized compounds using 1H NMR (homonuclear coupled and decoupled, and heteronuclear coupled and decoupled), and 13C NMR (1H coupled and decoupled)- Reviewed articles from peer-reviewed journals such as J. Med. Chem., ACS Med. Chem. Lett., Bioorg. Med. Chem., Bioorg. Med. Chem. Lett., etc.- Working knowledge of mass spectrometry and UV-vis spectrophotometry

Pittsburgh, Pennsylvania

- Assisted professors in grading examinations and labs (2014-2018)- Supervised and trained an undergraduate student in synthetic organic laboratory techniques which resulted in poster presentation at Undergraduate research symposium at Duquesne University (May – July 2017) and mentored three graduate students (2016- present)- Teaching assistant for Ability Based Lab Experiences (ABLE) (2012-2014)- Taught introductory molecular modeling to undergraduate and graduate students

Doctor Of Philosophy - Phd, Medicinal Chemistry

Bachelor Of Pharmacy - Bpharm, Pharmacy, 3.9

10+2, Science

Education record