Arpita Chowdhury, Ph.D. Email & Phone Number

Dresden, Sn, De

Dresden, Saxony, Germany

I work with leading discovery projects in cardiovascular diseases advancing them to PCC and accelerating translational research. Core competencies:Drug Discovery • Accelerated small molecule drug discovery CV programs, from target discovery, hit validation, candidate identification to lead optimization.Translational research• Established and integrated translational and preclinical animal models for PCC.• Implemented functional assays with invitro… Show more I work with leading discovery projects in cardiovascular diseases advancing them to PCC and accelerating translational research. Core competencies:Drug Discovery • Accelerated small molecule drug discovery CV programs, from target discovery, hit validation, candidate identification to lead optimization.Translational research• Established and integrated translational and preclinical animal models for PCC.• Implemented functional assays with invitro and organoid disease models.• Coordinated PK/PD modeling in close collaboration with DMPK and ADME experts.• Advanced biomarker identification through a multi-omics approach in collaboration with cross- functional teams. Technologies:• Leveraged emerging technologies, including CRISPR, high throughput functional assays in iPS- cardiomyocytes, high throughput screening and omics platform. Stakeholder engagement:• Experienced in engaging with internal and external stakeholders, including pharma partners, collaborators, KOLs, CROs, academic labs and C-suite executives.Project management and team leadership:• Lead and bring together cross-functional scientific teams for effective collaboration and productivity, pivotal to preclinical acceleration. • Collaborated with multidisciplinary teams for achieving project targets ensuring timelines and goals are met. Show less

Göttingen, Lower Saxony, Germany

Goettingen, Germany

In Prof. Peter Rehling's group. My research focus has been elucidation of molecular pathways in mitochondrial cardiomyopathies. Projects headed:1. ROS induced manifestation of cardiac hypertrophy in Barth syndrome (BTHS) models. Highlight: - Identification of ROS induced HIF1a and NFkB disease signaling pathway in iPS-derived Cardiomyocytes and shTAZ Mouse models for BTHS.2. Role of metabolic pathway switching in the progression… Show more In Prof. Peter Rehling's group. My research focus has been elucidation of molecular pathways in mitochondrial cardiomyopathies. Projects headed:1. ROS induced manifestation of cardiac hypertrophy in Barth syndrome (BTHS) models. Highlight: - Identification of ROS induced HIF1a and NFkB disease signaling pathway in iPS-derived Cardiomyocytes and shTAZ Mouse models for BTHS.2. Role of metabolic pathway switching in the progression of cardiac pathology in BTHS. Highlights: - Generation and establishment of CRISPR/Cas mediated patient-mutation Knock-in mouse model for BTHS. - Elucidation of the metabolic shift from FAO to Glycotic pathways in mouse heart and iPS- derived Cardiomyocytes resulting to cardiac failure. 3. MCU mediated mitochondrial calcium signaling in Coa6 patients derived iPS-cardiomyocytes. Highlights: - Generation of CRISPR/Cas mediated heart specific conditional KO mouse model for Coa6. - Elaborating calcium mediated signaling pathways leading to cardiac hypertrophy in mouse model and patient derived iPS-cardiomyocytes. Show less

Hannover Area, Germany

Thesis Title: Fibulin-6 and PTPR-σ: The cell-matrix anchors in adverse myocardial remodeling• Gained expertise in MI and TAC surgeries in mouse heart. • Extensive animal handling, dissections, tissue harvesting, organ perfusion.• Developed skills in cardiac tissue histology methods and microscopy (Fluorescence and confocal) • Molecular biology techniques (Western blotting, RT-PCR, ELISA assays).• Extensive cell culture experience including, primary cardiomyocyte and… Show more Thesis Title: Fibulin-6 and PTPR-σ: The cell-matrix anchors in adverse myocardial remodeling• Gained expertise in MI and TAC surgeries in mouse heart. • Extensive animal handling, dissections, tissue harvesting, organ perfusion.• Developed skills in cardiac tissue histology methods and microscopy (Fluorescence and confocal) • Molecular biology techniques (Western blotting, RT-PCR, ELISA assays).• Extensive cell culture experience including, primary cardiomyocyte and fibroblast isolation, immortalized mammalian cell line, their maintenance and experimentation.• Have established immortalized cardiac fibroblasts using 3T3 method. • Have been instrumental in creating primary cardiac fibroblast derived matrix for 3D cardiomyocyte culture. • Reviewed several manuscripts and have published 2 first author and 2 co-author research articles. Show less

New Delhi Area, India

Project 1: Genetic Analysis of HIV-1 subtypes Circulating in North India.•Genomic DNA isolation, PCR validation and sequence analysis from patient samples to find out the novel HIV-1 subtypes. Project 2: Combination of RNAi technology with novel catalytic DNAzyme and aptamers against HIV-1 genes.

Doctorate Of Philosophy (Phd), Cardiovascular Basic Research And Molecular Medicine

Master Of Science (M.Sc.), Molecular And Human Genetics

Bachelor Of Science (B.Sc.), Biotechnology

High School