Arun Mangadan Email & Phone Number

Princeton, New Jersey, United States

New York City Metropolitan Area

• During my tenure as a medicinal chemistry scientist at PTC Therapeutics, my dedication has been focused on uncovering treatments for neurological and rare diseases. I have been responsible for conceptualizing.
• Conducted in-depth Structure-Activity Relationship (SAR) analysis on hit compounds acquired via high-throughput screening and 3-D shape screening to enhance ADME properties, resulting in valuable contributions to.
• I analyzed activity, as well as pharmacokinetics/pharmacodynamics (PK/PD) data from DMPK teams, and effectively communicated the insights to a cross-functional lead optimization team, playing a vital role in the.
• Utilizing exceptional problem-solving skills, I have cooperated, supported, and fostered relationships with CMOs and CDMOs (external manufacturers) to facilitate process development, ensuring project alignment with.
• Proposed and submitted novel multi-step small molecule target projects to CROs; overseeing prompt delivery and continuously enhancing the API process.
• Obtained and analyzed NMR, HPLC, LC-MS, UPLC-MS, and UV data, meticulously documenting all procedures in the laboratory notebook (ELN).

Gainesville, Florida, United States

• Experienced project manager as demonstrated through the development of a novel enantioselective pi-acid catalyzed allylic substitution for the formation of lactones. This method, whereby a substrate with a poor leaving.
• Discovered and led the project on highly enantioselective addition of alcohols, carbon nucleophiles and amines to inactivated alkenes. The developed method simplified the access to biologically active molecules and.
• Excellent oral and written communication skills with the ability to coin innovative scientific projects, interpret and articulate scientific data as evidenced by eight national and international conference presentations.
• Trained to use and run the HRMS samples on Agilent LC/TOF and experienced in interpreting the data using Agilent MassHunter, which saved grant funds.
• Mentored two graduate students in techniques of organic synthesis, proper lab safety, maintenance of instruments, data interpreting software's and experiment planning; oversaw project implementation.
• Drafted technical standard operating procedures (SOPs) for various experiments and lab instruments.

• Pfizer Chemistry Connect (2021) │Oral Presentation
• American Chemical Society Spring (ACS) National Meeting and Exposition (2021) │Oral Presentation
• Southeastern Regional Meeting of the American Chemical Society (SERMACS) (2021)│Oral Presentation
• ACS, Florida section, Florida Annual Meeting and Exposition (FAME) Conference (2021) │Oral Presentation
• Three-minute thesis presentation, FCB & POLY/PMSE, University of Florida (2021) │Oral Presentation
• Graduate Research Symposium, University of Florida (2021) │Poster Presentation

Gainesville, Florida, United States

• Keen supply management and market knowledge utilized for ordering common consumables for Aponick research group and negotiating pricing with chemical companies (MillaporeSigma, Alfa Aesar, Fisher Scientific, Oakwood.
• Kept track of laboratory inventory to estimate the reorder time and quantity of supplies; preventing inventory stock-out or overstock.

Gainesville, Florida, United States

• Scientific consulting and people management ability resulted through supervising 200+ undergraduate students in organic chemistry techniques, laboratory safety and management
• Conflict resolution and problem solving skills as evidenced by preparing exams, proctoring and grading 100+ examinations and received excellent student evaluations.

Gainesville, Florida, United States

• Ensured all hazardous waste containers are properly labeled and categorized according to their chemical compatibility
• Maintained a safe and clean satellite accumulation area for hazardous waste
• Contacted the Environmental Health and Safety department to safely and properly dispose of hazardous waste

Bhopal, Madhya Pradesh, India

• Developed a synthetic strategy for a diverse array of isoquinolines and phenanthridines by a two-step, one-pot method constituting regioselective palladium-catalyzed Kuwajima−Urabe α-arylation of silylenol ethers and.
• Trained two new graduate students with the experimental background and laboratory techniques.

Bhopal, Madhya Pradesh, India

• Synthesized 2‑alkenylindoles and carbazoles via Palladium catalyzed α‑arylation of enones. Performed derivatization of these scaffolds as well.
• Acquired ample experience in understanding the project goals and experience in handling instruments like Parr Hydrogenator, H-Cube Hydrogenator, Kugelrohr, and HPLC.

Trivandrum, Kerala, India

• Study on the Rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins such as diazabicyclic olefins and urea-derived bicyclic olefins. Fused chromanone systems were synthesized in a single.
• Carried out Palladium mediated annulation reaction for the construction of functionalized heterocyclic molecules.
• Learned structure elucidation of various organic compounds using NMR techniques like 1H, 13C, COSY, DEPT., and Mass spectrometry.

Doctor Of Philosophy - Phd, Organic Chemistry, 3.91/4.0

Principal Investigator : Prof. Aaron Aponick, PhD Dissertation research focuses on Palladium Catalyzed Alkene Difunctionalization.

Annual Residential School On Medicinal Chemistry And Biology In Drug Discovery, Medicinal And Pharmaceutical Chemistry

Bs-Ms (Dual Degree), Chemistry, 9.19/10.0

Activities and Societies: The program integrates classroom learning with research and provides ample scope for multidisciplinary.

Organic Synthesis

High School Diploma, Chemistry, Physics, Mathematics, Biology, 94%

Middle School Diploma, Physics, Mathematics, Chemistry, Biology, Computer Science, 100%