Astrid Alsema Email & Phone Number

Rotterdam, Zh, Nl

Groningen, Groningen, Netherlands

• Applied bioinformatic tools for single-cel, bulk, and spatial RNA sequencing data using R and Python• Conducted dimensionality reduction, clustering, and visualization of large omics data using R• Collaborated with companies and international research institutes• Interpreted RNA sequencing results for scientific publications• Supervised students: project 1: Applied machine learning for spatial transcriptomics using Python project 2: Interactive web application for spatial transcriptomics using R Shiny

Groningen, Groningen, Netherlands

• Developed analysis pipelines for spatial transcriptomics data using R and Python• Implemented data quality control and preprocessing pipelines using Bash and R• Conducted statistical analyses using R• Reported and presented computational results• Consulted on data analysis

Tübingen Area, Germany

• Cultured human induced pluripotent stem cells• Implemented a parkin translocation assay• Performed viral transduction in vitro, DNA/RNA isolations, and quantitative PCRMaster Thesis: Investigating the effect of KARLN, SVOPL, and ZNF543 candidate genes from large-scale whole-exome sequencing on parkin translocation. 𝑠𝑢𝑚𝑚𝑎 𝑐𝑢𝑚 𝑙𝑎𝑢𝑑𝑒

Reutlingen Area, Germany

• Performed calcium imaging analysis, statistics, and 3D segmentation of cell organelles in microscopy images using Imaris and R

Tübingen Area, Germany

• Analysed two-photon calcium 3D-stack images using Matlab and ImageJ

Amsterdam Area, Netherlands

• Analysed electroencephalograms using graph theory and fast Fourier analysis• Implemented statistical analyses using SPSS

Amsterdam, North Holland, Netherlands

• Analysed electroencephalograms with fast Fourier analysis and minimum spanning trees• Selected for publication and presentation at Technical University Delft, for the Student Research Conference (November 26th, 2014)Bachelor Thesis: Microbleeds Are Related to Disturbed Oscillatory Brain Dynamics in Alzheimer Patients. 𝑠𝑢𝑚𝑚𝑎 𝑐𝑢𝑚 𝑙𝑎𝑢𝑑𝑒

Singapore

• Assisted exploration of directed drug delivery using magnetic microbubbles in vitro• Cultured mesenchymal stem cells

Master Of Science (Msc), Graduate School Of Cellular & Molecular Neuroscience,, Very Good (Top 20%)

• Relevant courses: Cell and Molecular Biology, Human Neurogenetics, Advanced Statistics. • Received Hertie Foundation Scholarship.

International Exchange Program

Bachelor Of Science (Bsc), Liberal Arts And Sciences, 𝑐𝑢𝑚 𝑙𝑎𝑢𝑑𝑒

• Relevant courses: Advanced Mathematics, Medicinal Chemistry, Immunology and Infectious Diseases, Advanced Developmental Biology.