Smriti Agrawal, Ph.D. Email & Phone Number

Portland, Or, Us

Keliomics is an emerging biotech company focused on revolutionizing drug development processes, particularly in the field of cancer treatment. Our innovative organ-scale biology platforms are designed to enhance preclinical testing by preserving human tissues and tumors ex vivo—outside the body—for extended periods. This technology enables a more accurate simulation of human biological responses, helping biopharmaceutical companies better predict a drug's efficacy before moving into clinical trials.We collaborate closely with pharmaceutical companies and academic institutions to accelerate drug development timelines, ensuring that our advanced technologies meet the specific needs of our partners. Our core technologies include the Kelion platform, which maintains the structure and function of primary human tissues, and OncoScreen, which facilitates advanced cancer diagnostics and patient-specific tumor modeling.Join us on our journey to transform drug discovery and improve patient outcomes!Visit us at https://keliomics.com/ to learn more.

Philomath, Oregon, Us

Philomath, Oregon, Us

Lazarus 3D is a medtech startup focused on improving patient safety and surgical outcomes through enabling patient-specific surgical rehearsals. Pre-Sure is a revolutionary surgical planning platform that extrapolates accurate and verifiable anatomical data from imaging scans such as MRI/CT, and provides surgeons an unprecedented opportunity to rehearse on a physical copy of their patients organs ahead of the curve. Pre-Sure medical devices are patient-specific and built in soft-tissue synthetic materials that cut and bleed like real tissue. Clinical evidence supports practical benefits of Pre-Sure, such as enhanced surgical planning, minimization of surgery time, as well as improvements in many other factors that can influence surgical outcomes. Pre-Sure is an FDA cleared medical device and is intended for diagnosis, patient management, treatment selection, and pre-operative surgical rehearsals. Personalized, precision surgical rehearsals are the cutting-edge of surgery today. Our mission is to build a future where we can eliminate the guesswork in surgery altogether by empowering doctors to operate with confidence. Lazarus 3D also values education as a pivotal path to success. Practice makes perfect, and confidence comes from preparation. Since its inception, Lazarus 3D has served the medical community by providing high-fidelity, anatomically accurate, medical education and training models for resident training for hundred's of surgical procedures, as well as rapid prototyped products for medical device development and demos. Lazarus 3D is a revolutionary company that is creating forward momentum in surgical care today for a safer and better tomorrow. Learn more at www.Lazarus3D.comReach out if you're interested in joining us in our mission to enable surgical perfection!

Houston, Texas, Us

My thesis research focused on validating the pathogenecity of variants identified by Next Generation Sequencing-based molecular diagnosis of patients with retinitis pigmentosa (RP) /leber congenital amaurosis (LCA) and using CRISPR-targeted knock-in and knock-out mouse models to elucidate the pathogenicity of candidate disease causing genes. In addition to characterizing the phenotype of disease conditions in animal models, my thesis also focused on identifying the molecular mechanisms by which loss of a gene’s function results in blindness. The translational aspect of my work utilized gene editing and AAV-based approaches to develop a successful, clinically validated gene therapy treatment for a rare, inherited form of blindness. Further continuation of these clinical efforts from bench to bedside will help prevent blindness in children and adults.

Newark, De, Us

-Specific Aims of study were to perform phenotypic characterization of lens in mouse mutants and to test the hypothesis that small Mafs regulate gene expression in the lens-Generated and characterized mouse mutants that carry various combinations of MafG and MafK null alleles, performed dissections of eyes and lens from embryonic and adult mice, histological analysis, immunostaining, analysis of microarray datasets, and other molecular methods to understand the role of MafG and MafK transcription factors in lens development/homeostasis. -Presented at seminars and conferences at University-wide and international level platforms

Newark, De, Us

-Instructed 4 lab courses (18 students/lab) on laboratory material, research design, and experimental protocol-Optimized experiments for efficacy and performed troubleshooting to satisfy teaching objectives-Assisted faculty with administrative tasks and curriculum development

-Researched systematics and biogeography of flea beetles in Dr. Catherine Duckett's lab at Monmouth University-Performed phylogenetic analysis of the flea beetles (Chrysomelidae: Alagoasa) based on 28S D2 rRNA and COI mRNA -Worked independently and collaboratively with Dr. Karl Kjer at Rutgers University to obtain valuable training in PAUP (Phylogenetic Analysis Using Parsimony) and MacClade bioinformatics software

-Continuing Research on Phylogenetic classification and Identification of Monophyletic Alagoasa species through physical character analyses and molecular approach -DNA sequence alignment

-Monmouth School of Science Peer MentorResponsibilities:-Meet with students periodically throughout the semester, both individually and in group activities -Provide guidance to seek necessary resources on campus for academic assistance, International student office resources, jobs, etc.-Assist students in developing the critical thinking skills through inviting speakers for workshops and advertising seminars on campus-Board member and Organizing committee for New Student Orientation and Peer Mentoring Orientation-Hosted Science Careers Roundtable Biology Panel

-Worked on drug development and quality analysis with the Research and Development team-Assisted in manufacturing of pharmaceutical dosage forms and analysis of finished products of controlled release and extended release generic drugs such as acetaminophen and cough syrups-Obtained valuable experience in working at a generic pharmaceutical lab

Founded the Waksman Science Club at JFK High School for all students interested in exploring opportunities in biomedical sciences. Built the curriculum alongside my mentor, Cathryn Crego, our instructor for the Waksman Summer Science Program and Science teacher at JFK high school, and my advisor, Dr. Andrew Vershon, from Rutgers University. - Secured equipment and resources to setup a small in-house research lab at the high school through a partnership agreement between the Waksman Institute and JFK High School- Recruited students to our organization across disciplines, growing memberships from 5 members to 50+- Wrote SOPs for trainings in sterile technique, laboratory techniques like cloning, DNA purification, PCR, Sanger analysis, NCBI data mining, data analysis, etc. Supported microbiology research projects and coordinated presentations for students with external experts-Raised funding from grants and scholarships to support the research needs as well as club sponsored events

-Part of three year Accelerated Research Program at JFK Memorial High School, where I conducted independent research by obtaining grants from Rutgers University, Young Science Achievers Program, and the NJ Academy of Science for my projects. -Conducted research under the guidance and supervision of Ms.Cathryn Crego (high school program director) Dr.Andrew Vershon (research mentor at Rutgers University)-Projects: Analysis of non-overlapping sequence in Artemia franciscana A Comparative Genomics Study. Population Genetic Structure and Genetic Differentiation of Artemia franciscana among Various Populations.

-Performed molecular techniques such as plasmid cloning, DNA purification, PCR, and Gel electrophoresis-Performed Sanger sequencing on novel DNA sequences isolated from sea monkeys (Artemia franciscana) to determine sequence homology, determine the 3D structure of the protein using Cn3D, and investigate the likely function of the protein -Published findings on GenBank database (NCBI)

Doctor Of Philosophy (Ph.D.), Human/Medical Genetics

Master Of Science (Ms), Biological Sciences

Bachelors Of Science, Biology (Molecular Cell Physiology) And Chemistry Minor