• Route scouting to provide solutions for the scale-up problems and GMP manufacturing of the APIs• Design and development of experimental strategies to identify and define critical process parameters• Execution and supervision of kilo scale production of demonstration/tox batches• Project management to ensure successful process development for timely delivery of targets

• Structure-based small molecule drugs: Developed the most potent BRD4/Jak2 dual inhibitors • Design and synthesis of novel Cereblon Inhibitors • De novo synthesis of Proteolysis Targeting Chimeras (PROTACs) • Glycogen Synthase Kinase-3 inhibitors (up to 14 steps complex synthesis)

Developed robust and reliable methods for diversity-oriented synthesis of biologically relevant molecules. Exploited the high iterative potential of the multi-component reactions (MCRs) in the context of post-condensation modifications to generate privileged scaffolds.Interests & major accomplishments: • Design and synthesis of novel dendrimer libraries as targeted drug delivery systems, exclusively based on the de novo MCR chemistry • Synthesis of arrays of pharmacologically relevant scaffolds using new post-reaction modifications of Passerini, Ugi, Mannich, Groebke-Blackburn-Bienayme, Petasis, and related reactions• Post-condensation modification of different variants of Ugi reaction leading to libraries of heterocycles such as quinoxaline, benzimidazol, benzodiazepine, and fused tetrazole • Preparation and submission of >800 compounds to NIH for biological screening• Parallel synthesis of a library of 5600 compounds

Focused on the asymmetric synthesis of amino acids precursors. Designed and synthesized organocatalysts to stereoselectively catalyze named reactions. Successfully carried out chemical transformations with high yields while utilizing the urea-based organocatalysts in Microwave Assisted Organic Synthesis (MAOS).Interests and major accomplishments: • Design and synthesis of organocatalysts for the stereoselective Mannich-, vinylogous Mannich-, and Michael-type reactions • Successful employment of α-amidosulfones as imine equivalent in the high yielding enantioselective Mannich-type reactions • Synthesis of Cinchona alkaloids based selective butyrylcholinesterase inhibitors