Principal Scientist
- Safety lead for small molecule and biologics projects- Target safety evaluation and risk/benefit analysis for early and late development projects under consideration of complex scientific data from various resources- Writing of summary reports from preclincal studies- Mining of clinical data for immunosafety and liver safety assessment- Infection risk assessment strategy for immunomodulatory portfolio- Design of host resistance studies- Project support with design of fit for purpose in vitro and in vivo studies (complement, cytokines,immunophenotyping) for mechanistic understanding of toxicological findings anddefinition of safe human starting dose- Collaboration with internal groups accross different disease areas (production, biomarker research, pharmacokinetics, clinical operations, data management and patient safety) to support preclinical and clinical studies
