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SKILLS AND EXPERTISE Experience on antibody display (Phage/Yeast) discovery and proteins engineering.• Patterns: BCMA, CD276, PSMA, FAP, LRRC15, CD5, TEM8 and more.• Generation of affinity maturation for higher specificity up to nanomolar range.• Write, review, and edit of standard operation procedures. Assistance and training laboratory staff.
Lentigen Technology
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Scientist IiLentigen Technology May 2018 - PresentGaithersburgGeneration of antibody display (scFv) on Phage/Yeast - Biopanning and construction - protein purification and characterization.
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ScientistDinova Pharmaceutical Inc Nov 2016 - Feb 2017Frederick, MdPanning a human Fab library against some cancer antigens, conversion some specific Fab to IgG and expression for assays.
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ScientistThe Henry M. Jackson Foundation For The Advancement Of Military Medicine Apr 2010 - Oct 2016Bethesda, Maryland 20814• Panned human Fab library against VSV-GP lyssavirus (ABLV, Australian bat lyssavirus), filovirus sGP – Obtained 2 human neutralization antibodies against rabies genus virus at nanomolar range and production on cell lines in mg range. • Construction vectors protein up-grade production (cell lines, IgG1- viral sGP and TfR). • Generation of phage display libraries (human naive and immunized Fab libraries).• Construction of bi-specific antibodies (anti TfR and ABLV). -
Visiting FellowNci Apr 2005 - Mar 2010Nci-Frederick, Md 21702Design and construction the domain heavy chain (CH2) antibody library for panning against HIV proteins, human cancer related receptor for the nanoantibody that binds to gp41 and inhibit HIV-1 entry in vitro.HIV-gp41 alanine scanning mutagenesis to figure out our set of anti-gp41 binding epitope and neutralize HIV-1 in vitro.Production of domain antibody (CH2 nanoantibody) and intact IgG1 in mg range for NMR study. -
Postdoctoral FellowSaic Jan 2000 - Mar 2005Nci-Frederick, Md 21702Designed and construction of camelized heavy chain antibodies for the two anti-CD22 antibodies (RFB4 and LL2) for testing functional nanobody derivered from the conventional antibody.Construction, expression and purification of sFv fusion anti-CD22 antibodies and RNase (EDN, RapL1 and Onconase) and successful improved the dimeric fusion protein that kill several CD22+ tumor cell line qith high efficacy (IC50= 3-20 nM).Optimized conditions for soluble expression of RNase fusion proteins.
Bang Vu Skills
Bang Vu Education Details
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Free University Brussels (Vrije Universiteit Brussels, Vub).Great Distinction.
Frequently Asked Questions about Bang Vu
What company does Bang Vu work for?
Bang Vu works for Lentigen Technology
What is Bang Vu's role at the current company?
Bang Vu's current role is Scientist - Molecular Biology, Microbiology & Immunology..
What is Bang Vu's email address?
Bang Vu's email address is ba****@****gen.com
What schools did Bang Vu attend?
Bang Vu attended Free University Brussels (Vrije Universiteit Brussels, Vub)..
What skills is Bang Vu known for?
Bang Vu has skills like Protein Expression, Purification, Cell Biology, Antibodies, Microbiology, In Vitro, Immunology, Mutagenesis, Primer Design, Phage Display, Vector Design, Vector Cloning.
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