Basil Uthuppu Email & Phone Number

Kvistgård, Capital Region, Denmark

Quality Assurance of Drug Product; Approval of Change Control, Deviations and CAPA; Release of Raw Materials; Batch Review of Final Drug Product.

Technical University Of Denmark, Kongens Lyngby, Denmark

I have been actively involved in various projectsProject 1: REWARD (REuse of WAteR in the food and bioprocessing inDustry)The main aim of this project is to reduce water consumption in the food and bioprocessing industry. This is achieved by maximizing reuse of process water and minimizing intake of potable water without compromising safety.Collaborators: København Universitet (KU) Food, Arla Food Ingredients, Novozymes A/SAchievements:• Implemented simple and novel colorimetric sensor technology for qualifying process water• Successfully conducted a large scale experimental campaign at KU using samples from Arla foodsProject 2: CRIM-TRACK (EU Project / FP7) Sensor system for detection of criminal chemical substances including explosives, drugs, precursors etc.Collaborators: Cranfield University UK, Pro Design Electronic GmbH Germany, Securetec Detections - Systeme AG Germany, Gammadata Instruments AB SwedenCustomers: Danish Emergency Management Agency, Dutch Customs, Lithuanian Police Development of colorimetric sensor prototype series for illicit chemical compound detection Machine Learning exercise to build database of known compounds Design and implementation of verification campaigns of prototype development process and documentation QA and Production of colorimetric chips with proper batch-based book keeping Troubleshooting problems related to dye formulations and spotting instrument in chip production, update protocols accordingly

Technical University Of Denmark, Kongens Lyngby

I have been actively involved in various research projectsProject 1: Nano-Iron for in-situ remediation of source zones contaminated with chlorinated solvents (DNAPL)The aim of the project was developing stable and reactive iron nanoparticles having mobility in aquifers for in-situ remediation of dense non-aqueous phase liquids (DNAPL) accumulated in the subsurface.Collaborators: Korea Advanced Institute of Science and Technology (KAIST) and DTU MiljøAchievements:• Successfully developed a surface modification approach in nanoparticle synthesis to obtain extremely stable nano iron particles in aqueous suspensions• Successfully synthesized extremely stable gold nanoparticles as tracers• Worked for 3 months in KAIST, South Korea as external stay of collaboration• Designed a simple spectroscopic method for detecting tracer particles during the external stayProject 2: Nanofilm (Co-supervisor of this PhD project)The goal of this project was to develop new materials to use in micro- and nanofabrication.Achievements:• Established a good synergy between Nanofilm and nano iron • Guided in synthesizing gold and silver nanoparticles with amphiphilic surface properties• Contributed to develop conducting silver nanocomposites that can be patterned and fabricated using cleanroom technologies• Supervised many bachelors/master studentsProject 3: External Consultant (2014 – 2015) for ALAPUM (ALternAtives to PUMp and treat)This project was to identify and evaluate new ideas as alternatives for pump and treat technology for remediating ground water contaminated with chlorinated organic solvent plumes.Achievements:• Represented DTU Nanotech in different brainstorming sessions of ALAPUM to discuss, evaluate and construct new ideas in the field• Actively participated in ALAPUM and contributed to different ideas, one of which obtained funding for a PhD project

Technical University Of Denmark, Kongens Lyngby, Denmark

Project : Colloidal Lithography technique for micro-structuring silicon wafers (NOx HTF project)Tasks and Responsibilities:• Synthesizing colloidal silica particles of different sizes• Co-supervising master student• Engaging into scientific discussion with parent project (NOx)Achievements:Successfully synthesized silica nanoparticles with different sizes and used them as masks in lithographic technique

The goal of the project was to develop an on-site method/prototype to detect pesticide residues in ground water as an early warning system at water supply centers. In Denmark ground water is the major source of drinking water (> 95%)Collaborators: De Nationale Geologiske Undersøgelser for Danmark og Grønland – GEUS (www.geus.dk) and DHI Solutions (www.dhi.dk)Achievements:• Published a thesis titled - ‘Design and Development of a Microfluidic Amperometric Immunosensor for the Quantitative Detection of 2,6- dichlorobenzamide (BAM) Herbicide Residue in Ground Water’• Successfully developed a working prototype for detecting herbicide residue - BAM• A modular microfluidic platform with in-built micro flow-injection analysis (µFIA) was designed and developed• A library of BAM hapten molecules were synthesized and the immunochemistry was optimized to regenerate the immunosorbent• Proof of concept was established by bringing the immunoassay from microtitre plates to a table top microfluidic device for repeated analysis

Master Thesis: ‘Synthesis, Characterization and Application as MRI contrast agent of Gadolinium Oxide Nanoparticles’ (A part of EU project – NanoEar (www.nanoear.org)This project involved synthesis, functionalisation and characterization of super paramagnetic gadolinium oxide nanoparticles meant to be used as negative contrast agent in MRI technique.

Doctor Of Philosophy (Ph.D.), Nanotechnology

Masters, Nanotechnology