Nick Bayhi Email & Phone Number

California, United States

Chicago, IL, US

I’m building in vitro and in silico tools to demystify protein conformational dynamics

New York, NY, US

Company creation

Chicago, IL, US

Cambridge, Massachusetts, US

Working with the team to make low-cost biosimilar insulin available to everyone

Washington, District Of Columbia, US

Engaging with policy efforts to make medicines more affordable to patients without stifling innovation in the drug industry.

Boston, Massachusetts, US

Sourcing and diligence for early stage life sciences companies, Seed-Series A

Chicago, Illinois, US

Curriculum (re)design, assignment support and grading, student support. Course is open to a mix of students from the science and business graduate schools at UChicago. Students are asked to identify novel biotech-focused IP from university tech transfer offices, and develop robust research and business plans to commercialize the technology.

New York, NY, US

- Diligence for early stage (seed through Series B) biotech investments, with a broad focus: ADCs, MAbs/BsAbs, small molecules, cell therapy, gene delivery (viral/nonviral), DNA sequencing, microneedles, contraception- Led Q&A with C-suites at over 25 companies; lead contributor to diligence on 50+ potential investments- Developed triage habits to identify.

Cambridge, Massachusetts, US

• Led development of cell-surface click conjugation platform to prototype protein constructs for preclinical data- Screened compounds with different reactivity and linker components to maximize protein copy on cell
• Created multiple site-specific conjugation techniques to orient protein constructs on the cell surface, better mimicking the presentation and function of constructs surface-expressed in our final product.
• Purified and characterized dozens of unique protein constructs, using AKTA and gravity columns- Protein A and IMAC affinity method development, including screening buffer and elution components- IEX and SEC to improve.

North Chicago, Illinois, US

Researching and optimizing methods for protein-small molecule conjugation and purification at small to medium scale, and the analysis of those conjugates and their processing in vitro and in vivo. Specific areas of research interest:- Novel cytotoxic and functional payloads- Nontraditional (non-antibody) protein constructs; Site-specific conjugation.

South San Francisco, California, US

• Built AKTA-scale protocols to enrich and isolate charged variants and drug-to-antibody ratio (DAR) variants from MAbs and ADCs using ion exchange and hydrophobic interaction chromatography
• Delivered product variants over 25x faster than existing methods; worked to establish this process as the platform for variant collection across departments in Pharma Technical Development

South San Francisco, California, US

• Established conjugation process and operating ranges used for Phase I manufacturing
• Leveraged size exclusion and hydrophobic interaction chromatography, Bioanalyzer, and Ellman’s assay to evaluate product quality and drug-to-antibody ratio throughout our conjugation process
• Pioneered a high-throughput Chip-TOF mass spectrometer method to localize drugs on our THIOMAB without peptide mapping; it has been adopted by the ADC group for early characterization of new ADCs

Medford, Massachusetts, US

• 2013-2014Thesis: Modular ECM Microcubes for Complex Tissue Constructs
• Fabricated decellularized microscale extracellular matrix blocks with native morphology
• Developed a protocol for processing ECM structures without digestion or crosslink agents
• Built diversely-shaped self-assembled tissues that promote vascularization, cell function
• Explanted rat livers and hearts to harvest primary cells and source extracellular matrix2012-2014Senior Capstone: Perfusion Bioreactor for High-Throughput Culture
• Invented a high-throughput reusable bioreactor system to maintain over thirty 3D tissue samples in parallel for up to two weeks with automated media recirculation

Medford, Massachusetts, US

• Worked one-on-one with all levels of students and professors in a variety of disciplines
• Experience proofreading and copy-editing large scientific and nonscientific manuscripts
• Prepared group workshops for technical & ESL tutoring, grant and journal article writing
• Presented a 70-minute Technical Writing workshop at the National Conference on Peer Tutoring in Writing, Tampa, FL, 2013.

Medford, Massachusetts, US

• Subject tutor for individuals and groups in biology, physics, math, and engineering science.

Medford, Massachusetts, US

• Assigned to a new class each semester, I worked with students (graduates and undergraduates) to improve their skills as writers through one-on-one meetings in which we discussed their essay drafts for the class. I met.

Doctor Of Philosophy - Phd, Biophysics

Master Of Science (Ms), Biomedical Engineering

Bachelor Of Science, Biomedical Engineering