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• Expertise in managing preclinical discovery and development of novel therapies for rare genetic diseases• Co-Founder of Zacharon Pharmaceuticals Inc, San Diego CA.• Proven ability to manage innovative science• Passion for building and supporting productive and collaborative teams• Excellent science communicator • Expert in lysosomal biology, glycobiology, cell-based assays, genetic diseases, and biomarkers• Passionate advocate for rare genetic diseases• Member of the Medical and Scientific Advisory Board of the Metachromatic Leukodystrophy Foundation• Advisor to Grace Science LLC• Artist exploring shapes and textures in clay (see crawfordceramics.com)
Biomarin
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Staff Scientist, Head Of The Musculoskeletal Therapeutic AreaBiomarin Jan 2013 - PresentSan Francisco Bay Area2021 - Current: Head of the Musculoskeletal Therapeutic Area. Responsible for the strategy and execution of therapeutic programs in the muscular and skeletal disease area. Managing a team of scientists to evaluate diseases and novel therapeutic approaches from both internal and external sources. Support the preclinical development of therapeutics in collaboration with therapeutic modality expertise.2018 - 2021: Head of the Analytical, Biochemistry and Cell Biology Department in Research, member of the Scientific Leadership Team. Managed a team of scientist that provide disease related expertise and assay development in support of preclinical therapeutic development across therapeutic modalities – small molecules, biologics, and gene therapy for rare genetic diseases. 2013 - 2018: Leadership of the Biology group within the Drug Discovery Department. Managed a team of scientist that provide disease related expertise and assay development in support of preclinical therapeutic development of small molecule programs. Team specializes in the identification and measurement of the primary events in a disease cascade to develop biomarkers proximal to the genetic lesion and to the point of therapeutic intervention. Leverage the data from these biomarkers for efficient preclinical and clinical decision making.2013 - Managed the integration of the Zacharon scientific staff into the BioMarin organization – initially as an independent laboratory site and eventually relocating the group to San Rafael. Retained critical expertise through the transition. -
Scientific AdvisorGrace Science, Llc May 2018 - PresentScientific advisor to Grace Science on the development of therapies and biomarkers for NGLY1 deficiency. NGLY1 Deficiency is an extremely rare genetic disorder caused by mutations in the NGLY1 gene, which results in the deficiency of an enzyme known as N-Glycanase 1. Patients with this disease suffer from a lifetime of debilitating symptoms including severe cognitive impairment, liver dysfunction, and motor defects.https://gracesciencellc.com -
Scientific AdvisorMld Foundation Nov 2017 - PresentScientific advisor the the Metachromatic Leukodystrophy (MLD) Foundation - provide technical knowledge and expertise. MLD is a rare genetic disease caused by the disruption of the ARSA gene the encodes a lysosomal enzyme that is require for the recycling of a glycolipid known as sulfatide. https://mldfoundation.org -
V.P. Of ResearchZacharon Pharmaceuticals Aug 2004 - Jan 2013Greater San Diego AreaCo-founder and VP of Research 2008 to 2013Co-founder and Director of Research 2004 to 2008Defined and guided the development of Zacharon’s science, vision, and strategy to diagnose and develop therapies for rare genetic diseases. Built Zacharon from a start-up to a fully equipped 16-person biotechnology company recognized for its expertise in glycobiology, drug discovery, biomarkers, and lysosomal storage diseases.Acquired over $18 million in funding for Zacharon through angel investors, venture investors, corporate partnerships and NIH grants (~$6 million in non-dilutive funding).Managed external scientific collaborations and contracts including a small molecule program partnered with Pfizer in a transaction valued at over $210 million in addition to numerous smaller corporate and academic collaborations and contracts. Managed the commercialization of the Sensi-Pro® assay technology. -
Ceramics TeacherUniversity Of California San Diego 1993 - 2012Greater San Diego AreaUniversity of California, San Diego Crafts Center - 2002 to 2012University of California, Davis Crafts Center - 1993 to 1997Taught beginning and advanced wheel throwing techniques and Raku glaze classes. -
Molecular BiologistList Biological Laboratories, Inc. 1997 - 1998San Francisco Bay AreaBrought recombinant DNA technology to List Biological Labs to generate pure isolates of bacterial toxin subunits. Designed and developed their first product derived from recombinant DNA technology. Developed understanding of glycans as receptors for bacterial toxins and their use as tools to study glycans. -
Lab AssistantUniversity Of California, Davis 1995 - 1997Davis, CaLab assistant in the Plant Pathology lab of Dr. Bryce Falk. Assisted scientist and post-docs in their laboratory and field based research. Gained critical laboratory and molecular biology experience.
Brett Crawford Skills
Brett Crawford Education Details
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Biomedical Sciences, Glycobiology -
Biology
Frequently Asked Questions about Brett Crawford
What company does Brett Crawford work for?
Brett Crawford works for Biomarin
What is Brett Crawford's role at the current company?
Brett Crawford's current role is Staff Scientist, Head of the Musculoskeletal Therapeutic Area in BioMarin Research.
What is Brett Crawford's email address?
Brett Crawford's email address is bc****@****mrn.com
What is Brett Crawford's direct phone number?
Brett Crawford's direct phone number is (858)-200*****
What schools did Brett Crawford attend?
Brett Crawford attended Uc San Diego, University Of California, Davis.
What skills is Brett Crawford known for?
Brett Crawford has skills like Biotechnology, Biochemistry, Drug Discovery, Molecular Biology, Cell Biology, Lifesciences, Protein Chemistry, Life Sciences, Assay Development, Cell Culture.
Who are Brett Crawford's colleagues?
Brett Crawford's colleagues are David Hinds, Christopher Mcgillem, Thomas Klindworth, Mohammed Azam, Lisa Mclernon (Neé Bohill), Peter Berg, Florence Camba.
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