Brian Larsen Email & Phone Number

Copenhagen, Dk

Capital Region, Denmark

Cell and molecular based in vitro assays to support application research in Planetary Health - Animal Biosolutions AR.>HTS cell-based screening incorporating automated liquid handling and data capture/analysis.>Isolation and culture of primary stem cells and intestinal organoids to support product mode of action understanding.>Responsible for directing the daily activities of 1-2 research associates.>Communication of research outputs to different levels across the organization and to customers.

Capital Region, Denmark

Cell and molecular based in vitro assays to support application research in Applied Industrial Biosolutions - Animal Health and Nutrition.>HTS cell-based screening incorporating automated liquid handling and data capture/analysis.>Isolation and culture of primary stem cells and intestinal organoids to support product mode of action understanding.>Responsible for directing the daily activities of 1-2 research associates.>Communication of research outputs to different levels across the organization and to customers.

Copenhagen Area, Denmark

Development of small molecule nuclease inhibitors and radiosensitizing drugs>Collaborative project aimed to apply structure-guided small molecule design and high throughput compound screening to develop novel radiosensitizing compounds to target tumour radioresistance.>Development of high-throughput robot-assisted biochemical and cell based screening platforms.>Successful establishment of a collaboration with a high throughput chemical biology consortium (CRO) to identify novel HITs, and arrangement of innovation funding (PreSeed) to finance the collaboration. Exploring the intersections between radiotherapy and inflammatory signalling>Delineating function of cell cycle control and molecular patterning (genome instability) with activation of inflammatory signalling following radiation.>Assessment of inflammatory signalling pathways.>Genetic CrispR screens

Copenhagen Area, Denmark

Identification and characterization of novel radiotherapy sensitizing targets relevant to the treatment of cancer. >High-throughput siRNA screening of cell cycle checkpoint effectors and genome stability factors following exposure to radiation>Specialised techniques: CrispR/Cas9 genome editing, Fluorescence Activated Cell Sorting (FACs), Quantitative Image Based Cytometry (QBIC) >Development and application of cell based assays to assess cell cycle/proliferation, cell viability/death, and genomic stability>Key Research Outputs: Internal and external collaborations leading to published and pending publications. Attraction of grant funding from several agencies

Ottawa, Canada Area

Characterisation of signal transduction, gene expression changes, and genome stability during skeletal muscle stem cell differentiation and development.>Cell and in vivo based approaches to assess skeletal muscle stem cell differentiation and function>Biochemical assays to monitor proteolytic and nucleolytic enzymatic activity>Utilisation of gene expression technologies (RNA interference and Transgene expression)>Key Research Outputs:Publication of primary research in high tier peer-reviewed journal of PNAS. Dissemination of primary research at international conferencesAttraction of PhD fellowship funding

Ottawa, Canada Area

Laboratory instruction of undergraduate students in a second year Genetics course with the Department of Biology.

Victoria, British Columbia, Canada

>Experienced team member with the development/scale up of proprietary plant tissue culture/ in vitro clonal platform.>Project lead in an internal quality control group. Signal monitoring and reporting of adverse process events to minimalize impact on product development.>Cryopreservation and cell bank management.

Victoria, British Columbia, Canada

>Experienced team member with proprietary in vitro plant cell culture development platform in a production setting.>Weekend/evening shift supervisor responsible for activities of 10-15 employees.

Doctor Of Philosophy (Ph.D.), Molecular Medicine

Bachelor Of Science (B.Sc.), Microbiology And Biochemistry

Activities and Societies: Biochemistry and Microbiology Student Society