Stephane Belin Email & Phone Number

Grenoble, Auvergne-Rhône-Alpes, France

Grenoble Area, France

The absence of treatment to overcome CNS regenerative failure is pointing out our lack of knowledge in the detailed mechanisms of neuronal growth, repair and their fine-tuning during development and injury. I will use a combination of in-vivo models of neuronal development, CNS injury (optic nerve and spinal cord), high throughput analysis and.

Unlike embryonic neurons, mature neurons from central nervous system lose the competence to regrow an axonal process after its ablation. It has been now well demonstrated that this poor regenerative ability is due to their intrinsic capability. In order to counteract this phenomenon, we need to understand the molecular changes induced by the injury within.

Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process. Ribosome biogenesis is a very complex process involving transcriptional as well as many post-transcriptional steps to produce functional ribosomes. It is now well demonstrated that.

The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). My work show that after infection of human cells with herpes simplex virus type 1 (HSV-1).

Doctor Of Philosophy (Ph.D.), Biochemistry And Molecular Biology, Ph.D

Master'S Degree, Molecular Biology

Licence Degree, Biochemistry And Molecular Biology

Habilitation À Diriger Des Recherches Hdr, Neurobiology And Neurosciences

Activities and Societies: Translation regulation in normal and pathological conditions