Innovative bioengineer focused on advancing the field of gene therapy and pushing new therapies toward reality.• 11 years of experience with AAV gene therapy design, engineering, production, and delivery, both in vitro & in vivo• 10 years of experience with CRISPR and other gene editing technologies• Expertise with in vivo models of disease, especially in the retina and the CNS• Proficiency in managing cross-team collaborations, including government–industry partnerships• Skilled at communicating research concepts, goals, and results to both expert and lay audiences• Strong ability to develop and implement streamlined, goal-focused research plansSpecialties: Gene therapy, AAV, gene editing, in vivo mouse work, cell culture, molecular biology
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Scientist, R And DPrecigenWashington, Dc, Us
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Scientist, R&DPrecigen Aug 2024 - PresentGermantown, Maryland, UsI work as an R&D Scientist in the Adenovector research division of Precigen.
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Postdoctoral FellowThe National Institutes Of Health Jul 2018 - Jul 2024Bethesda, Md, UsAs a member of Dr. Bill Pavan's group (Genetic Disease Research Branch, NHGRI), my work focused on AAV-based gene therapy for the rare neurodegenerative disease Niemann-Pick disease, type C (NPC). I worked on generating and testing new therapeutic AAV vectors both in vitro and in vivo in murine models of NPC using a variety of techniques, including both behavioral analysis and molecular and tissue assays to assess and improve the efficacy of new approaches to treatment. -
Phd CandidateUniversity Of California, Berkeley Aug 2011 - Dec 2017Berkeley, Ca, UsPhD research on AAV-based gene therapy in the retina using genome-engineering technology.• Developed and tested AAV-based gene editing therapy for dominant genetic diseases in the retina• Designed and patented new self-inactivating CRISPR variants for safer gene editing• Created new AAV variants for gene therapy with novel characteristics -
Postbaccalaureate FellowNih Jul 2010 - Jul 2011Bethesda, Md, UsResearcher in the Laboratory for Cellular and Molecular Immunology in NIAID (National Institute for Allergy and Infectious Disease) studying the systems biology of T cell development.• Studied gene expression networks from microarray data to analyze unknown gene function in T cell development• Wrote software to process and analyze raw data to generate causal gene expression networks• Validated gene functionality in vivo
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Undergraduate ResearcherMit Wittrup Lab Sep 2009 - May 2010Cambridge, Ma, UsUndergraduate researcher in Professor Dane Wittrup's antibody engineering laboratory. Worked on designing a bispecific antibody construct for cancer therapy.• Designed, produced, and characterized a novel bispecific antibody construct leading to a patent -
Summer InternWeizmann Institute Of Science Jun 2009 - Aug 2009Rehovot, Hamerkaz, IlStudied the role of microtubule-associated proteins in cell migration and metastasis. -
Summer Undergraduate Research FellowMayo Clinic Jun 2008 - Aug 2008Rochester, Minnesota, UsSummer research student in the Isobel Scarisbrick Neuroscience Laboratory assessing the role of kallikreins on lymphocyte apoptosis and proliferation in progressive multiple sclerosis. -
Summer Undergraduate Research FellowMayo Clinic Jun 2007 - Aug 2007Rochester, Minnesota, UsSummer research student in the Chella David Immunology Laboratory examining effects of COX-2 inhibitors in superantigen-induced toxic shock on CD4+, CD8+, and regulatory T cells."Evaluating the role of HLA-DQ polymorphisms on immune response to bacterial superantigens using transgenic mice": https://pubmed.ncbi.nlm.nih.gov/18086265/
Benjamin Epstein Education Details
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University Of California, BerkeleyBioengineering -
University Of California, San FranciscoBioengineering
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Massachusetts Institute Of TechnologyBiological Engineering
Frequently Asked Questions about Benjamin Epstein
What company does Benjamin Epstein work for?
Benjamin Epstein works for Precigen
What is Benjamin Epstein's role at the current company?
Benjamin Epstein's current role is Scientist, R and D.
What schools did Benjamin Epstein attend?
Benjamin Epstein attended University Of California, Berkeley, University Of California, San Francisco, Massachusetts Institute Of Technology.
Who are Benjamin Epstein's colleagues?
Benjamin Epstein's colleagues are Enayat Nikoopour, Sherry Triplett, Joe Merkert, Ros Franklin, Henil Patel, Hema Dimaggio, Xiuming Zheng.
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