Graduate Researcher
Vancouver, British Columbia, Ca
Performed research leading to a PhD from the University of British Columbia: Areas of scientific expertise include human and mouse cellular immunology and immune regulation; lymphocyte development and function including mouse models used for their study; antigen receptor genetics and signal transduction mechanisms; molecular mechanisms of RAS GTPase regulation and oncogenesis. Technical expertise includes flow cytometry including phenotypic analysis, cellular assays for proliferation and apoptosis; cell culture of adherent and non-adherent cell lines, primary human and mouse leukocytes; techniques in molecular and cellular biology and molecular cloning.Articles published in refereed journals1. Klinger, M.B., Guilbault, B., Goulding, R.E., and Kay, R.J. (2005) Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. Oncogene, Apr 2005; 24(16): 2695-704.2. Guilbault, B., and Kay, R.J. (2004) RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. J. Biol. Chem., May 2004; 279: 19523 - 19530.3. Klinger, M.B., Guilbault, B., and Kay, R.J. (2004) Dbs promotes expansion of DN thymocytes and deletion of double positive and single positive thymocytes. Eur. J. Immunol., Mar 2004; 34(3): 806-16.4. Archibald, F., Valeanu, L., Leichtle, G., and Guilbault, B. (1998) Nonspecific Chlorination of Organics: a Chemistry Unique to Human Industry? Water Quality Research Journal of Canada 33(3): 347-62.