Benjamin Tuck Email & Phone Number

Cambridge, GB

Cambridge, England, United Kingdom

I am a CNS biologist at Astex Pharmaceuticals, supporting small molecule structure-based drug discovery across a range of projects. My roles and responsibilities include:- Development of robust cell-based assays to profile compounds in high-throughput formats.- Use of automation technologies to enhance compound profiling throughput and accuracy..

Cambridge, England, United Kingdom

As an Associate at Lucy Cavendish College, I am involved in academic college activities and a regular attendee of social college events.

Cambridge, England, United Kingdom

• In my Postdoctoral research, I investigated the endolysosomal mechanisms underlying dendritic cell cross-presentation. This project involved the development of a novel cell-based 96-well plate assay which relies on.
• Mouse handling and isolation (PIL AB License Holder)
• Naïve CD8+ T-cell purification and culture
• Multicolour flow cytometry, compensation and FlowJo analysis
• Dendritic cell culture
• Protein purification

Cambridge, United Kingdom

During my PhD, I investigated the mechanisms by which tau assemblies enter the cytosol of cells during neurodegenerative disease. While previous studies suggested that cytosolic entry might be rate-limiting, no assay existed to quantify this in real-time. I developed a cell-based assay to quantify the cytosolic entry of tau in real-time. This assay was.

Gateshead And Glasgow

I worked at JD Sports throughout my Undergraduate degree. This enhanced my time management skills as I had to study around work (20 hours per week). I also gained customer-facing sales experience and supervisory experience of new recruits who needed training.

Glasgow, United Kingdom

• In my Honours project at the Unibersity of Glasgow, I was interested in the interactions that occur between mesenchymal stem cells and leukemic stem cells within the bone marrow during disease. To investigate this.
• Suspension of spheroids in Collagen via a Transwell system.
• Visualisation of leukemic stem cell invasion by fluorescent microscopy.
• Transmission and scanning electron microscopy to visualise interaction.

Cambridge, United Kingdom

-MedImmune is a global biologic development company and part of the Astrazeneca research group. -12 Industrial placement students each year work alongside world-class scientists in state of the art facilities on an individual research project, contributing to MedImmune's robust pipeline.-I used the CRISPR/dCas9-VPR system to transiently increase antibody.

Glasgow

-CRISPR/Cas9 nickase experimentation to mutagenise target sites at the AAVS1 locus in HEK293 cells.-Gained a great deal of experience in academic lab work and became familiar with lab life.-Regularly attended lab meetings and 1-on-1 discussions with the lab leader and/or my supervisor.-Developed a wide range of skills and techniques including HEK293 tissue.

Doctor Of Philosophy - Phd, Clinical Neuroscience

Molecular And Cellular Biology Msci (Hons), Molecular Biology, 1St Class Msci (Hons)

Activities and Societies: -A member of both the Biochemistry, Molecular Biology and Genetics society, and the Infection and Immunity.

Education record

- 10 GCSEs A*- C - As level English Language - A - A level Biology - B - A level Geography - B - A level Physics - C