- Development and application of large-scale, molecular resolved, kinetic in silico models for metabolism of various organs by modeling each enzyme with a kinetic rate equation. By including the regulatory properties of all enzymes these network models integrate the knowledge from decades of biochemical research and enable quantitative predictions of systems’ behavior. - Functional interpretation (genotype-phenotype relation) of high-throughput multi-omics data (proteomics, metabolomics).- Development and application of in silico tissue models that take into account tissue architecture including microvascular structure and perfusion for metabolic functions.