Bernhard Drotleff Email & Phone Number

Heidelberg, Baden-Württemberg, Germany

-Personnel Management and Leadership: Led facility operations, overseeing staff recruitment, supervision, and training.-Strategic Development: Formulated and executed forward-looking strategies, fostering innovation and piloting new technology.-Operational Excellence: Ensured seamless facility operation, maintaining high-quality services and implementing quality control protocols.-Resource Management: Efficiently managed requests, samples, data, and resources, optimizing workflows… Show more -Personnel Management and Leadership: Led facility operations, overseeing staff recruitment, supervision, and training.-Strategic Development: Formulated and executed forward-looking strategies, fostering innovation and piloting new technology.-Operational Excellence: Ensured seamless facility operation, maintaining high-quality services and implementing quality control protocols.-Resource Management: Efficiently managed requests, samples, data, and resources, optimizing workflows and data processing. Show less

Heidelberg, Baden-Württemberg, Deutschland

-Mass Spectrometry Expertise: Developed and optimized mass spectrometry assays for targeted/untargeted metabolomics and lipidomics, conducting diverse biomarker discovery studies across various biological sample types.-Instrumentation Proficiency: Skilled in operating and maintaining advanced liquid chromatography and high-resolution mass spectrometry instruments (UHPLC, Orbitraps, Triple-Quadrupoles etc.).-Project Management and User Guidance: Advised users on experimental design, data… Show more -Mass Spectrometry Expertise: Developed and optimized mass spectrometry assays for targeted/untargeted metabolomics and lipidomics, conducting diverse biomarker discovery studies across various biological sample types.-Instrumentation Proficiency: Skilled in operating and maintaining advanced liquid chromatography and high-resolution mass spectrometry instruments (UHPLC, Orbitraps, Triple-Quadrupoles etc.).-Project Management and User Guidance: Advised users on experimental design, data analysis, and provided customized reports to facilitate data interpretation and decision-making. Show less

-Method Development and Validation: Created methods for quantifying steroids and hormonal contraceptives in plasma and saliva, facilitating large-scale clinical use. Conducted protein measurements for structural validation and specialized in fractionation and offline 2D-LC for bioactive compound identification.-Instrumentation Management: Oversaw and maintained LC-MS systems, including Agilent 1290 Infinity, Sciex TripleTOF5600+, QTRAP 4500, and API 4000.-Metabolite Screening and… Show more -Method Development and Validation: Created methods for quantifying steroids and hormonal contraceptives in plasma and saliva, facilitating large-scale clinical use. Conducted protein measurements for structural validation and specialized in fractionation and offline 2D-LC for bioactive compound identification.-Instrumentation Management: Oversaw and maintained LC-MS systems, including Agilent 1290 Infinity, Sciex TripleTOF5600+, QTRAP 4500, and API 4000.-Metabolite Screening and Structure Elucidation: Performed phase I metabolite screening and structure elucidation for new drug candidates using LC-MS and liver microsome incubation.-Mentorship and Supervision: Provided guidance and training to master's students, visiting researchers, and Ph.D. candidates in untargeted lipidomics and LC-MS techniques. Served as Head Teaching Fellow for "Instrumental Analysis" and "Biochemistry - Drug Metabolism" courses. Show less

Tübingen, Baden-Württemberg, Deutschland

Thesis title: "Development and Optimization of Targeted/Untargeted Lipidomic Screening Methodologies in Pharmaceutical and Clinical Bioanalysis by Liquid Chromatography-High Resolution-Mass Spectrometry"-Analytical Method Development: Created LC-MS methods for both targeted and untargeted analyses, with a focus on relative and absolute quantification, ensuring compliance with FDA bioanalytical method validation guidelines.-Sample Preparation Expertise: Proficient in diverse sample… Show more Thesis title: "Development and Optimization of Targeted/Untargeted Lipidomic Screening Methodologies in Pharmaceutical and Clinical Bioanalysis by Liquid Chromatography-High Resolution-Mass Spectrometry"-Analytical Method Development: Created LC-MS methods for both targeted and untargeted analyses, with a focus on relative and absolute quantification, ensuring compliance with FDA bioanalytical method validation guidelines.-Sample Preparation Expertise: Proficient in diverse sample preparation techniques and extraction from various matrices (plasma, dried blood spots, faeces, dental biofilms, platelets, cells, and cell media).-Data Processing and Scripting: Established efficient data processing workflows and crafted customized R scripts for untargeted lipidomics. Show less

Berlin, Deutschland

Thesis title: "Development of a liquid chromatography-tandem mass spectrometry-based method for therapeutic drug monitoring of antiretroviral substances in human plasma"

Master Of Science, Toxicology

Thesis title: "Development of a liquid chromatography-tandem mass spectrometry-based method for therapeutic drug monitoring.

Bachelor Of Science, Pharmaceutical Sciences

Thesis title: "Cloning of AAV-vectors for the viral gene therapy of retinitis pigmentosa" Conducted under the supervision of Prof. Dr..