Bill Denney Email & Phone Number

Massachusetts, USA

Cambridge, Massachusetts, USA

Cambridge, Massachusetts, USA

• Led clinical pharmacology aspects of multiple drug development programs supporting rapid, quantitative, integrated, validated decision making during individual clinical studies, within a development program, within a.
• Developed model based meta-analyses of diabetic endpoints (HbA1c, FPG, body weight) to guide therapeutic-area decision making.
• Led team and developed tool for automated monitoring of phase 1 studies to ensure complete, validated, traceable study monitoring improving monitoring quality and decreasing turn-around time.
• Optimized quality in phase 2 study read-out by automating data quality checks and coordinating a team to rapidly building models for all primary and secondary safety and efficacy endpoints in parallel with the top-line.

West Point, Pennsylvania

• Led seven modeling and simulation teams to inform dosing, dosing regimen, compound and program go/no-go decisions providing >$50M in POS and NPV adjusted earnings.
• Represented drug metabolism and pharmacokinetics (DMPK) on product development teams in diverse disease areas including diabetes, pain, obesity, thrombosis, neuroscience, and women's health.
• Managed interaction between DMPK and IT for implementation of software and compute cluster in compliance with 21 CFR Part 11 for NONMEM, WinNonlin, and other programs.
• Officially mentored three scientists to teach NLME modeling practice and instructed/advised many others to optimize modeling for accuracy and speed. Supervised and co-supervised two interns for mechanistic modeling.
• Provided training courses on software, modeling, and computational methods.
• Helped develop new first in human dose prediction methods evaluating PBPK, IVIVC, and allometry.

Managed and implemented existing and new mission critical systems and networks for multiple nationwide medium sized businesses.

Lagrange, GA

• Developed novel simulation techniques for rapidly equilibrating real systems using molecular dynamics: Responsible for implementation of algorithms to rapidly sample phase space for polymers to reach meta-stable glassy.
• Designed and implemented reactor automation with computerized data acquisition and analysis of a gas phase packed bed reactor for implementation of novel fuel cell applications.
• Designed experimental protocol and conducted laboratory scale experiments in cleaning a hydrocarbon feedstock of catalyst poisons.
• Completed the calculations necessary to predict the equilibrium yields for an acid-catalyzed isomerization reaction involving substituted arenes. Verified the calculations with experiments. Assisted in gathering the.

Phd, Chemical And Biomolecular Engineering

Activities and Societies: AIChEPh.D. Candidate • Evaluated the kinetic response of various plasma and platelet activators and inhibitors.

Ms, Chemical And Biomolecular Engineering

Bs, Chemical Engineering