Bin Deng Email & Phone Number

Boston, Ma, Us

Greater Boston Area

• Develop breast imaging modality by combining functional diffuse optical tomography (DOT) with conventional structural 2D mammogram and validate concept in a 34-sample clinical trial;• Innovate tissue segmentation algorithm to generate anatomical prior to guide image reconstruction.

Syracuse, New York Area

• Played leading role in planning and executing a military contract of investigating hematocrit, plasma protein and fluid shifting in a simulated internal hemorrhage scenario based on a cannulated rat model. The design of model includes 5 controls/baseline, 5 jugular vein cannulated rats for controlled blood loss, and 3 carotid artery cannulated rats for severe hemorrhage with various fluid replacement combinations.• Developed and tested the first portable non-invasive continuous plasma volume and hematocrit monitoring prototype for clinical settings, and coordinated with nephrologists and nurse practitioners to collect clinical trials data for 9 volunteers at a local dialysis center.• In charge of clinical data processing, analysis, and interpretation using MATLAB, OriginPro, MS Excel and OEM software.• Responsible for technical writings including protocols for Institutional Review Board approval for animal research, informed consent for clinical study, quarterly and annual reports to funding sources, research and business plan, as well as managing data and log archives.• Assisted software engineers in implementing proprietary algorithm into C++ based OEM software, and helped to improve the GUI functionality and debug the source code.

1-014 Center For Science And Technology

• Successfully implemented in-house prototype engineering of two generations of NIR Raman systems that adopted sophisticated human factor engineering including a unique human-machine interface that enables real-time pressure and contact area monitoring for continuous noninvasive medical applications.• Conducted thorough and systematic in vitro investigation on NIR fluorescence and photobleaching characteristics of various tissue constituents, such as collagen, melanin, hemoglobin, albumin, antioxidants, porphyrins and advance glycation endproducts (AGEs), using Raman, UV-Vis, steady-state and time-resolved fluorescence, DLS, etc.• Utilized Raman and fluorescence spectroscopy in characterizing biochemical changes during glial scar formation 4-days, 2-weeks and 4-weeks post traumatic spinal cord injury in a rat model and classification analysis based on hallmark peaks of structural proteins and proteoglycans demonstrated convincing results.• In charge of in-house optical system alignment, calibration, trouble shooting, CCD performance evaluation, and new user training.• Performed on daily basis spectral data processing, analysis, and interpretation, including dark current correction, instrument function correction, fluorescence background suppressing, data smoothing, and SNV, using MATLAB, GRAMS, OriginPro, and OEM software.• Documented and maintained voluminous data, reported scientific results, published 4 peer-reviewed papers and 4 conference proceeding papers, and presented research on 6 prestigious international conferences (oral presentations on SPIE Photonics West 2010 & 2012, posters on ICORS 2010, OSA, etc) and various institutional seminars.

0-035 Link Hall Of Engineering

-- Lab instructor for BEN 305/605 & BEN 306/606: "Engineering Analysis in Living System I & II"• Main responsibilities: 1) draft syllabus & lab instructions 2) equipment setup & debugging 3) LabVIEW and ImageJ orientation 4) in-class trouble shooting & grading• Scale of course: extracellular recording from earthworm nerve cord, sensory coding by a mechanoreceptor, vector electrocardiogram, action potential recording of frog gastrocnemius muscle, ion transport in toad bladder, whole animal plethysmography, and exercise physiology.-- Lab instructor for CHE 103: "General Chemistry"• Main responsibilities: 1) conduct lab demonstration 2) supervise safety & grading• Scale of course: paper chromatography, acid base titration, Redox reaction, estimating the caloric content of nuts, pH, heats of reaction, clock reaction.

• 2 years hands-on experience with NIR absorption, FTIR and ATR spectroscopy in the project of extracting analyte specific signal from heavily overlapping spectra.• Performed bench-top wet chemistry experiments including various biological samples, such as BSA, human albumin, plasma, and whole blood, to validate the innovatively proposed internal reference wavelength method.• Teamworked in validating the methodological feasibility in a rabbit model using a in-house built double beam transvenous NIR absorption spectrometer;• Built multivariate calibration models using Unscrambler and MATLAB for NIR spectra collected from 30 diabetic patients in a 2-week clinical OGTT study, and evaluated the model robustness by varying sampling techniques, sample size and validation set strategies.• Prepared the end-of-project evaluation presentation for a five-year Chinese NSF grant.

Tianjin, P.R. China

• Teamworked in the development of a differential optical absorption spectroscopy (DOAS) air quality monitoring system using NIR spectroscopy;• Assisted senior optical engineers in optical & mechanical design using AutoCAD;• Researched on environmental engineering regulatory documents, and built a database on project-relevant ISO, EN, and GB standards.

Doctor Of Philosophy (Ph.D.), Bioengineering And Biomedical Engineering, 3.833

Activities and Societies: AAAS, SPIE, WISE-FPP, SFBDissertation: "The role of fluorescence and human factors in quantitative transdermal.

Master Of Science (M.S.), Precision Instrument & Optoelectronics Engineering, 3.82

Dissertation: "Theoretical and experimental study of effective extraction of glucose specific signal in NIR spectroscopy"

Bachelor Of Science (B.S.), Biomedical Engineering

Senior thesis: "Mechanical design and application of DOAS (Differential Optical Absorption Spectroscopy) system for atmospheric quality.