Bingnan Gu, Phd, Mba Email & Phone Number

Basel, CH

Basel, CH

Basel, CH

• Lead and execute innovation in AAV GMP manufacturing platforms as the founding scientist in the viral vector R&D
• Set up research direction and plans, and track timelines for multiple R&D activities. Manage risks and uncertainty and propose mitigation plans for challenging projects and make Go/No Go decisions
• Communicate project progress regularly in R&D and across functional groups within the company. Maintain strong interaction with PD/BAS/QC/QA/RA, and provide scientific training, analytical support, and problem-solving.
• Recruit, coach, align and motivate new colleagues, direct reports, and contractors to ensure the smooth onboarding and progressive performance improvements
• Project scouting, scoping, and managing for Lonza sponsored research in top AAV labs in academia
• Subject matter expert in AAV biology and gene therapy. Evaluate new concepts and technologies from academia and industry with Lonza CD and LI units in business trips and formulate strategies for implementation in AAV.

Houston, Texas, US

• Explored the roles of multiple deregulated epigenetic modifiers in prostate cancer and breast cancer metabolism using PDX mouse models
• Engineered Lentivirus-mediated inducible shRNA for controlled gene knockdown in cancer cell lines

Houston, TX, US

• In silico screened 774 RNAseq, CNV, and patient survival data from TCGA database for breast cancer, and nominated candidate biomarkers/drug targets in the list of histone methylation modifiers/readers
• Interrogated epigenetic regulators, via gene knockout/knockdown and pharmacological inhibition, for functions in cell survival/ proliferation/differentiation/invasion in human breast cancer cells or mouse breast stem.
• Established the cutting-edge CRISPR/CAS9 gene editing platform in the laboratory in two months. Generated Knockout/ Knockin mouse ES cell clones for three genes with refined screening methods
• Designed and bred multiple genetic mouse models for three histone modifiers in parallel and in combination for cancer and normal development studies, and transformed the lab animal protocols to new online system to.

Irvine, CA, US

• Unraveled genetic and epigenetic regulation of mouse breast stem cells by Wnt signaling co-activator Pygo2 with multi-lab collaborations using multidisciplinary approaches
• Garnered a three-year postdoctoral fellowship award based on attaining the highest merit score in the tumor progression section among 16 applicants in California
• Proved a critical role to earning a competitive new NIH R01 grant that led to an expansion in laboratory staff and resources

San Antonio, TX, US

• Explored novel molecular and cellular function of tumor suppressor protein CtIP in the maintenance of genome stability and control of cell differentiation
• Served as a key team player and contributed in several fundamental findings of BRCA1 function in breast cancer, including the promotion of breast cell differentiation and suppression of breast tumor angiogenesis

Mba

Phd, Molecular Medicine

Bs, Life Sciences