Bin Gui Email and Phone Number
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As a passionate and innovative cancer biologist and group leader, I would like to dedicate my expertise in molecular and cancer cell biology, leadership skills, and problem-solving skills to advancing cutting-edge research and driving innovation in the field of drug development. I have 10+ years of hands-on oncology research experience, especially 5+ years of experience in the pharmaceutical industry, including 2 years of leading our Platform. I am confident I will make a difference in your drug-hunting journey. 🌟 Expertise • Drug Target Discovery, Identification and Validation• Successful Preclinical Candidate Advancement• Data-Driven Decision-Making• Collaborative Cross-functional Team Leadership🏆 Achievements• Strategically co-led Ribon’s BEACON+ Platform and fostered an innovative and collaborative culture, enabling high productivity and the timely delivery of 5+ targets for drug discovery programs/projects• Led cross-functional biology team and managed multiple CROs to successfully identify and validate a handful of high-value drug targets for oncology via various in vitro and in vitro approaches • Design and executed IND-enabling studies that led to the delivery of two clinical assets and multiple pre-IND stage pipelines• Contributed to 30+ publications with 1000+ total citations.• People managed 1 Ph.D. level scientist and mentored multiple co-ops/interns🔬 Skills✦ Cross-functional Team Leadership ✦ Project Management ✦ Drug Discovery ✦ Cellular Pharmacology ✦ Molecular and Cell Biology ✦ Assay Development ✦ Functional Genomic Screening ✦ Large Dataset Mining with R ✦ NGS Data Analysis✦ Immunofluorescence Assay ✦ Anti-Tumor Immunity ✦ FlowI am actively seeking new career opportunities where I can make a significant impact on the advancement of innovative therapeutics. If you are looking for a collaborative and self-motivated group leader with a passion for innovation and a dedication to transforming scientific discoveries into life-changing therapeutics, let's connect!📧 Feel free to reach out: [easter0731@gmail.com] #PharmaceuticalRnD #DrugDiscovery #EarlyDrugDevelopment #ResearchAndDevelopment
Entact Bio
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Principal ScientistEntact Bio Nov 2023 - PresentWatertown, Massachusetts, Us
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Principal ScientistRibon Therapeutics Jun 2022 - Aug 2023Cambridge, Massachusetts, Us- Strategically co-led Ribon’s Platform and fostered an innovative and collaborative culture, enabling high productivity and the timely identification and evaluation of 5+ novel immuno-oncology drug targets- Led target validation team and managed CROs to successfully evaluate therapeutic and chemical biology hypotheses for a handful of oncology drug targets via various in vitro and in vivo approaches- Contributed to the strategy development and decision-making during the hit-to-lead transition and lead optimization of a protein degrader program that targeted oncology and inflammatory diseases- Wrote and QC’ed reports for regulatory filing, resulting in 1 IND and 1 IB filed- People managed 1 Ph.D. level scientist and mentored 3 co-ops/interns -
Senior ScientistRibon Therapeutics Aug 2020 - Jun 2022Cambridge, Massachusetts, Us- Served as in vitro biology lead for a preclinical program that focuses on inflammatory diseases, contributing to the strategy development and decision-making - Established and conducted high-throughput cell-based arrayed CRISPR screening in collaboration with the translational medicine team, resulting in the establishment of the responder hypothesis for a first-in-class small molecule inhibitor, refining its MOA, and publications in high-impact journals- Established and optimized high-throughput multiplexed cell-based assays, enabling the cellular pharmacodynamics profiling of several small molecular inhibitors and degraders
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ScientistRibon Therapeutics Aug 2018 - Aug 2020Cambridge, Massachusetts, Us- Established functional genomic screening platform and conducted 40+ genome-wide NGS-based pooled screening, resulting in the discovery of novel synthetic lethality events, and refining of the responder hypothesis of the tool compounds and lead compounds- Conducted in vitro target validation in-house and managed CROs to support novel drug target identification and validation- Generated 25+ Cas9 overexpressing cancer cell models and enabled mini cell panel screen for target dependencies, resulting in great improvement of target validation efficiency
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Postdoctoral Research FellowHarvard Medical School Nov 2014 - Aug 2018Boston, Ma, Us -
Postdoctoral Research Fellow ♦ Lab ManagerBrigham And Women'S Hospital Oct 2014 - Aug 2018Us- Established and utilized the CRISPR screening and data analysis pipeline in collaboration of Dana-Farber Cancer Insititue, leading to the discovery of 100+ biomarkers for PARPi and BETi drug resistance and 1 peer-reviewed publication- Established multiple cellular and cell-free assays, resulting in the characterization of various clinical compounds and drug candidates - Led a research team to unravel novel MOA for PARP inhibitors via a wide range of in vitro and in vivo experimental approaches, leading to 4 peer-reviewed publications and 2 grants.- Served as first postdoc and participated in lab establishment and training of 5+ research fellows. -
Postdoctoral Research FellowThe George Washington University Jan 2014 - Oct 2014Washington, D.C., Us• Working closely with my colleagues, I contributed to a project focusing on epigenetic enzyme MTA1 and AKT signaling pathway, and published two reviews on a peer-reviewed journal. A figure I designed was selected as the journal cover image. -
Postdoctoral Research FellowPeking University Health Science Center Aug 2012 - Nov 2013Cn• Help establish and optimize the PCR-based molecular approach for the diagnosis of amyotrophic lateral sclerosis (ALS)• Led a team and cloned C9orf72 – one of the genes the cause of 9p21-linked ALS -- and characterized its biological and pathological function
Bin Gui Skills
Bin Gui Education Details
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Peking UniversityBiochemistry And Molecular Biology -
Peking UniversityBasic Medical Science
Frequently Asked Questions about Bin Gui
What company does Bin Gui work for?
Bin Gui works for Entact Bio
What is Bin Gui's role at the current company?
Bin Gui's current role is Platform Biology Lead | Principal Scientist in Drug Discovery | Transforming Ideas into Breakthrough Therapies.
What is Bin Gui's email address?
Bin Gui's email address is ea****@****ail.com
What is Bin Gui's direct phone number?
Bin Gui's direct phone number is +120243*****
What schools did Bin Gui attend?
Bin Gui attended Peking University, Peking University.
What skills is Bin Gui known for?
Bin Gui has skills like Molecular Biology, Biochemistry, Cell Culture, Cell Biology, Molecular Cloning, Biotechnology, Research, Teamwork, Protein Expression, Project Management, Life Sciences, Western Blotting.
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