Phillip A. Patten, Phd Email and Phone Number
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Self-directed and driven biotechnology entrepreneur with comprehensive accomplishments leading life sciences research, drug discovery and development, strategic alliances, grant preparation and administration, intellectual property strategy, and cross-functional teams to achieve business goals. An innovative thinker with strong directed evolution, synthetic biology, bioinformatics, and immunology acumen. Demonstrated success in pioneering scientific innovations for fast-paced, dynamic startups. Recognized for driving discovery research and early pre-clinical development programs and projects, ensuring compliance with budget, staffing, and timeline requirements. Expertise includes managing biotechnology companies, partnerships, platform technologies, and sitting on both boards of directors and scientific advisory boards. Accomplishments:• Co-founder and CSO of DiCE Molecules; industrialized Harbury DNA-encoded library platform and used it to discover potent inhibitors of multiple challenging protein-protein interface targets; advanced oral small molecule inhibitors of IL17A into pre-clinical studies.• Supported the discovery and development of ZEMDRI, an aminoglycoside antibacterial injectable.• Led team that discovered ACHN-975, the first LpxC inhibitor for the treatment of multidrug-resistant gram-negative bacterial infections advanced into clinical testing,• Led team that discovered evolved interferon-alpha (IFN-α) and advanced into Phase 1 safety studies in tandem with Roche, a global leader in pharmaceuticals and diagnostics.• Co-inventor on commercially launched glyphosate resistance trait.• Secured and administered $64M+ in grants for Achaogen and Maxygen.• Built teams of 60+ high-performing scientists.• Pioneered a fully automated, seamless-cloning capable, synthetic biology platform.• Published numerous articles and awarded 90+ U.S. patents.Expertise:Start-ups, Strategic Alliances, Entrepreneurship, Intellectual Property, Angel Investing, Venture Capital, Board of Directors, Federal Grants Management, Antibodies, Crispr, Gene Editing, Small Molecules, Agricultural Chemicals, Out-licensing, Intellectual Property Law, Patent Portfolio Management, CRO Management, Gene Synthesis, Clinical Development, Cell Biology, Assay Development, Oncology, Key Opinion Leaders, Natural Products, Clinical Trials, New Drug Application (NDA)
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Entrepreneur In ResidenceApple Tree PartnersUnited States -
Chief Scientific OfficerInitial Therapeutics Oct 2020 - Present
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Entrepreneur In Residence And Cso Initial TherapeuticsApple Tree Partners Oct 2020 - Dec 2021New York, New York, Us -
Founder, Chief Scientific OfficerDice Molecules 2014 - 2020A provider of innovative therapies in immunology for patients with debilitating diseases.• Established and grew the business to 35 employees with a substantial research and development budget, including identifying and securing angel investors, raising $50M in venture capital funding, and developing strategic partnerships with Sanofi and Genentech.• Served on the board of directors from 2013 through 2019.• Managed the scientific and intellectual property strategy, budgeting, scientific staff, and operations.• Achieved clinical candidacy for an oral Interleukin 17A (IL-17A) inhibitor drug.• Improved the Harbury DNA-encoded library platform by exclusively licensing the intellectual property from Stanford University and reinventing the DNA router in tandem with an external engineering team.
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Director, Trait Engineering Technology & Dupont FellowPioneer Hi-Bred 2010 - 2014A provider of seeds for agriculture and a major producer of genetically modified organisms (GMO) with $4.3B in revenue.• Built and developed a team of 60+ scientists overseeing directed evolution, synthetic biology, insect toxin engineering, gene synthesis, and gene editing.• Spearheaded the research and development efforts as a valued member of the leadership team.• Co-managed a strategic alliance with Arzeda, a biotechnology and software company designing custom evolved genes for herbicide resistance applications using directed evolution, synthetic biology, and computational methods.• Improved operations by executing quarterly site reviews and ensuring quality output.• Pioneered a fully automated, seamless-cloning capable, synthetic biology platform with the capacity to construct and NGS-verify 4,000 vectors annually.• Reduced labor costs by transforming processes via automation.• Drove innovation in herbicide and insect resistance field testing by developing ultra-high content insect imaging assays leveraging laboratory automation, machine learning, and artificial intelligence.• Developed intellectual property strategies for directed evolution assets in tandem with legal professionals.
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Senior Vice President, BiologyAchaogen 2004 - Jun 2010South San Francisco, Ca, UsA biopharmaceutical company.• Recruited and oversaw 12 microbiologists, geneticists, and toxicologists, supporting antibiotic drug discovery and development; authored and administered government grants, and led the team to discovery inhibitors of the zinc-dependent metallo-enzyme LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase).• Enabled long-term business stability by securing $62M in grants with the Defense Advanced Research Projects Agency (DARPA) and the Defense Threat Reduction Agency (DTRA).• Worked with legal and business teams to develop intellectual property strategy.• Expanded treatment options for advanced urinary tract infections (UTI) by supporting the discovery and development of ZEMDRI, an aminoglycoside antibacterial injectable.• Pioneered ACHN-975, the first LpxC inhibitor in clinical testing, for the treatment of multidrug-resistant gram-negative bacterial infection, including designing animal studies, enabling efficacy at practical doses, identifying and mitigating chemical liabilities, and collaborating with contract research organizations (CRO).• Enabled revenue growth by identifying, recommending, and leading new projects. -
Vice President, TechnologyMaxygen 1996 - 2004Sunnyvale, California, UsA biotechnology company pioneering the application of Directed Evolution methods in the fields of industrial enzymes, agriculture, protein therapeutics, and vaccines. Focused on the discovery and development of improved versions of protein drugs through internal discovery research and external collaborations.• Oversaw 12 protein therapeutics scientists and cross-divisional directed evolution technology initiatives.• Authored and administered a $2M grant with the Advanced Technology Program (ATP).• Advanced evolved interferon-alpha (IFN-α) for the treatment of Hepatitis C into clinical development in tandem with Roche as part of a strategic alliance. • Enhanced profitability by co-discovering Optimum GAT, an alternative glyphosate-tolerant trait by achieving a 10,000X improved enzyme activity.• Enabled market share growth by focusing on evolved biologics as a key business opportunity.• Increased employee engagement by coordinating cross-divisional scientific initiatives.
Phillip A. Patten, Phd Skills
Phillip A. Patten, Phd Education Details
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Stanford UniversityBiology -
CaltechBiology
Frequently Asked Questions about Phillip A. Patten, Phd
What company does Phillip A. Patten, Phd work for?
Phillip A. Patten, Phd works for Apple Tree Partners
What is Phillip A. Patten, Phd's role at the current company?
Phillip A. Patten, Phd's current role is Entrepreneur in Residence.
What is Phillip A. Patten, Phd's email address?
Phillip A. Patten, Phd's email address is pp****@****ail.com
What schools did Phillip A. Patten, Phd attend?
Phillip A. Patten, Phd attended Stanford University, Caltech.
What skills is Phillip A. Patten, Phd known for?
Phillip A. Patten, Phd has skills like Clinical Trials, Agricultural Chemicals, R&d Operations, Small Molecules, Cell Biology, Crispr, People Management, Chemistry, Synthetic Biology, Antibodies, Angel Investing, Genomics.
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