Birgit Klaproth Email & Phone Number

Copenhagen

Assay technology, implementing and improving protocols and instruments

Hørsholm Municipality, Capital Region Of Denmark, Denmark

Direct production activities:- Production activities starting with the responsibility for preperation of steril aerobic or anaerobic media for DS production and being part of the production team for LBP including inoculation, fermentation and down stream formulation.- Supply chain, inventory of materials and items for DS production.Indirect production.

Hørsholm Municipality, Capital Region Of Denmark, Denmark

Development of enumeration methods for anaerobe bacteria using different methods: CFU, MPN and Flow cytometryLaboratory and equipment responsible for e.g. glove boxes.Cultivation of anaerobic bacteriaSupply chainMedia preparation for development of anaerobic bacteriaOrganization and timeline planning for moving and renovation of laboratories

Hørsholm

Work within analytical methods for live biotherapeutic products:OptimazationAdaptationAutomationTrouble shootingDocumentation & presentation Transfer between research and productionSet up of laboratories and laboratory responsibleRepresentative in the safety organization

Måløv, Denmark

Research on binding kinetics of different proteins by SPA assays using solubilized receptors and membranes (also high throughput by using robot) as well as whole cell binding and non labelled competitive association assays.Development of new cell-based assays for ligand binding studies, internalization and recycling,Setting up and integrating new.

Måløv, Denmark

Development of new strategies to measure binding kinetics. Biacore instrument from GE Healthcare and ITC were implemented in specific projects.Development of a broader knowledge of cell culturing of mammalian cells.Competitive binding studies using whole a cell strategy.

Gentofte

Competitive binding studies using whole a cell strategy:- competition assays- association and dissociation studiesPre-project work focusing on modern insulins and incretins

Getofte, Denmark

Competitive binding studies using whole a cell strategy.Work on protein signalling by using the NanoPro1000: state-of-the-art technology of combining isoelectric focusing of proteins with western blotting technology.

Gentofte, Denmark

Competitive binding studies using whole a cell strategy.Work on protein expression, purification and characterization using a 2-step purification protocol combined with enzymatic digestion, RP-HPLC and SELDI-TOF.Work on protein signalling by using state-of-the-art technology on isoelectric focusing of proteins combined with classic western blotting in the.

Gentofte, Denmark

Molecular Biology for cloning of insulin analogues and expression in yeast as well as protein purification using an ÄKTA FLPC and HPLC. For upscale purpose, I implementer a 5-l-fermentor in the department.Support of master and PhD students in the daily laboratory work and by teaching and performing tasks on the different chromatography.

Henningsdorf, Germany

Research within biocombinatorics of polyketide synthases and how to increase the expression of secondary metabolites in streptomyces. For both projects, combined molecular biology, microbiology and analytical chemistry.Cell culture and microbiology:- Cultivation of different bacterial and fungi on solid media and in flask culture - Isolation of new stains.

Paris Area, France

Isolation and characterization of mutant strains of Cryptococcus neoformans with a modified capsule structure

Grenoble Area, France

Study of the purification and the structure of the matrix protein M1 of the influenza virus

Dipl.-Ing (Fh), Chemietechnik / Biotechnologie

Bta - Biologisch-Technischer Assistent

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