Biao Li Email & Phone Number

Redwood City, California, Us

On target to outsmart cancer

Redwood City, California, Us

• Analytics lead on developing and launching Proteograph XT, a high-throughput product for deep unbiased pretomics• Designed and deployed large-scale cloud-based analytics platform enabling everyone in the company to process and make sense out of data on an easy and user-friendly manner• Exemplified and onboarded team with best coding practices in collaborative projects, enhancing reproducibility, shareability and readability of internal repositories• Set strategies, roadmaps and supervised team towards accomplishing data science goals• Built a CNN classification model using raw mass spectrometry intensity image maps enabling real-time QC procedure with >99% accuracy detecting sample contamination or operational errors• Strategized and prototyped a question & answering chat system over internal documents / datasets leveraging LLMs and fully open-sourced packages, greatly boosted productivities and freed data retention concern• First-authored 3 posters and presented at ASMS and US-HUPO conferences, co-authored 2 IP applications

San Diego, Ca, Us

• Data science liaison of bioinformatics collaborative support for on-market NIPT products, guiding and advising colleagues across functional units on addressing NIPT related technical affairs • Enabled new material for VeriSeq NIPT field use of PQ and competency testing• Performed modeling/simulation of large-scale genome-wide case studies, implemented quantitative guideline for explaining atypical testing results of VeriSeq NIPT assay• Investigated escalated issues, performed root cause analysis and evaluated risk of impact on assay performance • Contributed to design and verification test of TruSight Oncology 500 assay.

San Diego, Ca, Us

• Improved accuracy on estimating key parameter for VeriSeq NIPT classification algorithm• Assessed testing data for 70+ new NIPT customers globally, examined and resolved data/pipeline issues, evaluated impact on assay performance, identified areas of improvements for future products• Refined protocols of PQ, competency testing, and reagent kit QC, accounting for confounding factors• Developed and deployed interactive webapps empowering field scientists to quickly resolve commonly seen data inquires from customers

San Diego, Ca, Us

• Automated data collection, preprocessing, analysis, visualization and report generation pipelines for evaluating performance qualification and customer competency testing data of NIPT products• Analyzed testing data and enabled 30+ new installations of NIPT customers globally• Contributed to method developments and troubleshooting investigations.

Houston, Texas, Us

• Investigated and developed statistical model and simulation framework for rare variant association/admixture mapping• Collaborated in establishing computational pipeline to clean, annotate and analyze Next-generation Exome Sequence data• Designed a statistical model to generate pedigree based rare variant sequence data for both Mendelian and Complex traits, and implemented the simulation program• Developed a novel statistical method to detect nonparametric genetic linkage in data with large locus heterogeneity

Houston, Tx, Us

• Elucidated the sampling effect with intrinsic systematic inter-species differences on studying the evolution of microsatellite loci using stochastic modeling• Developed simulation framework for population based rare variant sequence data studies, evaluated performance of rare variant statistical association methods, and demonstrated there is no single most powerful method• Built a Monte Carlo simulation model to characterize DNA replication rate during cell cycles• Established a Branching Process stochastic model to study connections between cell fates in hippocampal neurogenesis and examined key unknown parameters, e.g. apoptotic rate

Houston, Tx, Us

• Lectured weekly review sessions and supervised students in graduate-level course of Probability in Bioinformatics and Genetics

Houston, Tx, Us

• Unraveled effect of known family histories on genetics association studies, employed study design model and performed simulation studies• Contributed in design and development of utility modules for simuPOP, a population genetics simulation environment.

Doctor Of Philosophy (Ph.D.), Bioengineering - Top 10 Bioe Program (Statistical And Computational Track)

Bachelor'S Degree, Bioengineering