Michael O'Keefe

Michael O'Keefe Email and Phone Number

Director - Small Molecule Process Chemistry and Quality by Design @ Gilead Sciences
Michael O'Keefe's Location
San Francisco, California, United States, United States
Michael O'Keefe's Contact Details

Michael O'Keefe work email

Michael O'Keefe personal email

About Michael O'Keefe

CMC leader and scientist in the Process Chemistry department at Gilead Sciences, a biopharmaceutical company in the San Francisco bay area. Relevant experience includes early and late stage API development, regulatory filings, Quality by Design (QbD), Design of Experiments (DOE), Design Space, kilo lab and pilot plant GMP operations, and people management.Former postdoctoral fellow of the American Cancer Society in synthetic organic chemistry at Stanford University under the supervision of Prof. Barry M. Trost, where I developed several transition metal catalyzed transformations, as well as two total syntheses.Doctoral training was accomplished at the University of Texas at Austin under the direction of Prof. Stephen F. Martin. Successfully completed the total synthesis of a complex natural product, and also discovered a novel carbonylative transition metal catalyzed process.Specialties: Synthetic organic chemistry; Process chemistry; Total synthesis of complex, biologically intriguing molecules; Asymmetric catalysis.

Michael O'Keefe's Current Company Details
Gilead Sciences

Gilead Sciences

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Director - Small Molecule Process Chemistry and Quality by Design
Website:
gilead.com
Michael O'Keefe Work Experience Details
  • Gilead Sciences
    Director
    Gilead Sciences Apr 2024 - Present
    Foster City, Ca, Us
  • Gilead Sciences
    Senior Research Scientist Ii
    Gilead Sciences Mar 2022 - Apr 2024
    Foster City, Ca, Us
  • Gilead Sciences
    Senior Research Scientist I
    Gilead Sciences Feb 2017 - Mar 2022
    Foster City, Ca, Us
  • Gilead Sciences
    Research Scientist I
    Gilead Sciences Aug 2013 - Feb 2017
    Foster City, Ca, Us
  • Stanford University
    Acs Postdoctoral Fellow
    Stanford University Sep 2010 - Jul 2013
    Stanford, Ca, Us
    Examined the total syntheses of the complex alkaloids communesins A and B, as well as the total synthesis of the macrolide Leustroducsin B. Also developed several transition metal catalyzed transformations, including a novel asymmetric dearomative trimethylenemethane (TMM) cycloaddition with nitroarenes, a TMM cycloaddition with nitroolefins, and a ruthenium catalyzed redox isomerization, tandem cyclopropanation.
  • University Of Texas At Austin
    Graduate Research Assistant
    University Of Texas At Austin Aug 2004 - Aug 2010
    Austin, Tx, Us
    Completed the total synthesis of the complex C-aryl glycoside isokidamycin by the application of an intramolecular aryne-furan cycloaddition methodology developed in the Martin group. Also discovered novel carbonylative cross-coupling conditions for the synthesis of aryl ketones from ortho-disubstituted aryl iodides.
  • U.S. Geological Survey (Usgs)
    Hydrologic Technician
    U.S. Geological Survey (Usgs) Jun 2002 - Jul 2004
    Reston, Va, Us
    Collected environmental water, sediment and animal tissue samples throughout Wisconsin, the Florida Everglades and the Experimental Lakes Area in Ontario, Canada. Analyzed environmental samples for organic and inorganic mercury levels using cold vapor atomicfluorescence spectroscopy, as well as inductively coupled plasma mass spectrometry. Other responsibilities included maintaining a clean-lab environment and data management.
  • University Of Wisconsin-Madison
    Undergraduate Research Assistant
    University Of Wisconsin-Madison Sep 2002 - Jun 2004
    Madison, Wi, Us
    Synthesized intermediates related to the F-ring of the marine natural product Halichondrin B.

Michael O'Keefe Skills

Organic Chemistry Chemistry Mass Spectrometry Organic Synthesis Synthetic Organic Chemistry Lc Ms Nmr Spectroscopy Nmr Medicinal Chemistry Hplc Drug Design Heterocyclic Chemistry Uv/vis Science Organometallic Chemistry Total Synthesis Inorganic Chemistry Fluorescence Spectroscopy Drug Discovery Characterization Ir Nuclear Magnetic Resonance Customer Satisfaction Natural Product Synthesis Design Of Experiments Liquid Chromatography Mass Spectrometry Uv/vis Spectroscopy Asymmetric Catalysis Process Chemistry

Michael O'Keefe Education Details

  • The University Of Texas At Austin
    The University Of Texas At Austin
    Organic Chemistry
  • University Of Wisconsin-Madison
    University Of Wisconsin-Madison
    Chemistry

Frequently Asked Questions about Michael O'Keefe

What company does Michael O'Keefe work for?

Michael O'Keefe works for Gilead Sciences

What is Michael O'Keefe's role at the current company?

Michael O'Keefe's current role is Director - Small Molecule Process Chemistry and Quality by Design.

What is Michael O'Keefe's email address?

Michael O'Keefe's email address is bm****@****ail.com

What schools did Michael O'Keefe attend?

Michael O'Keefe attended The University Of Texas At Austin, University Of Wisconsin-Madison.

What are some of Michael O'Keefe's interests?

Michael O'Keefe has interest in Social Services, Yoga, Civil Rights And Social Action, Education, Environment, Science And Technology, Running, Disaster And Humanitarian Relief, Human Rights, Animal Welfare.

What skills is Michael O'Keefe known for?

Michael O'Keefe has skills like Organic Chemistry, Chemistry, Mass Spectrometry, Organic Synthesis, Synthetic Organic Chemistry, Lc Ms, Nmr Spectroscopy, Nmr, Medicinal Chemistry, Hplc, Drug Design, Heterocyclic Chemistry.

Who are Michael O'Keefe's colleagues?

Michael O'Keefe's colleagues are Alisha Kumar, Ruben Giraldo, Srinivasa Kondragunta, Janghyeon Im, Amey Shroff, Pharmd, Fabiana Konishi, Satish Dunna.

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