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Development of automated high content screening platform for drugs that improve mitochondrial function in live primary neurons: from culturing to analysing high content images and automating data analysis by python.

Development of water soluble, photostable and non-phototoxic myosin II inhibitors (patent: WO2017129782A1) by applying enzyme-, cell-based and in vivo assays using zebrafish embryos. Development of photoreactive myosin II inhibitor to confine inhibitor effects to subcellular locations applying two-photon microscopy, a technique named molecular tatoo.

Investigating the different structural states of the enzyme myiosin by developing photoreactive myosin II inhibitors.

Structural background of force generation in myosin II. Identified a region in the enzyme that is specifically responsible for its activation by actin and force generation, as investigated by cloning, in vitro enzyme kinetics and in vivo in C. elegans.

Applying molecular biology techniques to induce mutations in the enzyme myosin and express the enzyme in Dyctiostelium discoideum.

Drug induced differentiation of chronic myeloid leukemia cells.