Boyd Steere Email & Phone Number

Indianapolis, Indiana, United States

o Current role: Senior Director of Bioinformatics in Translational Immunology. - Biology lead for the NDA submission of mirikizumab. - Translational lead for clinical trials of mirikizumab in IBD, including late-phase tissue single-cell and spatial experimental design and analysis. - Identifies novel targets, patient subpopulations, and biomarker profiles for systemic autoimmune diseases by building workflows and analyses primarily in R, supplemented with Python, SQL, JMP, and Spotfire.

Indianapolis, Indiana Area

- Led Immunology Bioinformatics' use of single-cell multi-omics data. - Biology team leader for ongoing small molecule drug discovery program developed around a target identified through bioinformatics analyses. This program included writing and managing grants to support external academic collaborations.

Indianapolis, Indiana Area

- Led a small team of programmers and analysts in biomarker study workflows.- Leveraged similarity in the sequence and structure of families of related proteins to enrich ligand libraries for screening and scaffold hopping in support of drug development teams pursuing challenging targets. This effort successfully led to nanomolar hits in a program where traditional in-silico modeling and screening libraries had failed. - Predicted PK profiles and variability explained by metabolic gene polymorphisms using in vitro data, in silico predictions of compound ADME properties, and modeling and simulation methods. - Characterized ADME/Tox-related gene splice isoforms and differential expression patterns using array chip and RNAseq methods to identify marker profiles associated with specific induction pathways.

Indianapolis, Indiana Area

- Scientific Lead on the Tailored Therapeutics Workbench project, which was the principle software platform for data aggregation and integration for the pharmacogenetics biomarker label claims for Effient® (prasugrel). - Integrated and analyzed an atherosclerosis genotype-phenotype data set in collaboration with a human tissue bank in The Netherlands. This work included due diligence, requirements specification, experimental design, and the analysis of multivariate clinical and in-vitro data sets for genetic association to plaque structure.

Volunteer member on one of several teams of 10 superforecasters each working on near-term (up to one year) predictions of geopolitical and scientific questions using open-source information.

Greater Los Angeles Area

o Designed, programmed, and oversaw the commercial release of ADMET Modeler™; an automated predictive cheminformatics model builder that employs a wide variety of machine learning, set selection, and dimensionality reduction methods (C++,VB). This module was licensed by the US FDA in 2008 and by the US EPA in 2009.o Created neural network and support vector machine predictive models of the ADME/Tox properties of small molecules. These properties included multiprotic pKa profiles, logP, logD, solubility, hERG receptor binding, rat and mouse chronic carcinogenicity, epithelial cell layer and BBB permeabilities, plasma protein binding, volume of distribution, rat estrogen receptor toxicity, salmonella mutagenicity, minnow acute toxicity, and various metabolic endpoints.

Greater Los Angeles Area

Via acquisition of NeXstar Pharmaceuticalso Computationally modeled thermodynamic differences between therapeutic and toxic enantiomers of drugs, as well as interactions between drug molecules and plasma membranes.o Increased manufacturing efficiency by developing process automation applications.o Coded viscometer and spectrophotometer device drivers and user interfaces.o Administered UNIX workstations.

Phd, Biochemistry And Molecular Biology

o Determined the high-resolution structure of the protein diphtheria toxin (DT) by X-ray crystallography. o Discovered close structural.

Bs, Biochemistry

Research Assistant: o Developed educational software describing molecular orbitals and thermodynamics. o Supervised 30-station student.