Brad Niles Email & Phone Number

Davis, California, Us

ARIZ Precision Medicine is targeting cancer at the root cause, a genetic error that occurs early in the cancerization of humans. Our lead drug candidate is undergoing proof of concept studies in animal models of lung cancer. We have drug candidates for breast, colon, liver, lung, ovarian and prostate cancer that we will be testing over the next 12-18 months. We have several partnerships already and intend to add a strategic partner to license our cancer drug candidates. We were recently honored by several organizations for our efforts in the cancer field.

Davis, California, Us

• Supported and drove new innovation in product development• Identified and established agreements with strategic partners to drive technology development• Worked with CEO to identify and secure investments• Mentored a team of PhD students in the UC Davis Big Bang business competition

Davis, California, Us

• Lab manager for new startup, started lab operations, identified and hired staff• Project leader for proof of concept experiments for development of pre-clinical drug candidates• Experienced with numerous in vitro and in vivo drug testing approaches• Inventor on multiple patent applications

Oakland, California, Us

• Project leader for engineering yeast for production of high levels of multiple biofuel compounds• Achieved a high level of heterologous gene expression, monitored pathway intermediates by LC-MS and final products by GC-MS• Developed screen for identification of high copy DNA integrations in yeast.• Use of S. cerevisiae and oleaginous yeast

Davis, California, Us

• Performed microarray analysis to identify defect in reactive oxygen stress (ROS) response pathway involved in regulation of actin cytoskeletal architecture• Utilized genetic screening to identify novel feedback loop for regulation of sphingolipid metabolism• Re-engineering of metabolic signaling pathways to restore signaling defects• Lab managing, including training and managing of students

Davis, California, Us

• Designed and implemented experiments which identified novel form of kinase regulation that involved targeting through a protein-protein interaction• Identified multiple pro-growth kinase targets through in vitro and in vivo protein expression screens• Performed kinase active site genetic re-engineering to develop specific inhibition of kinases

Davis, California, Us

Utilized molecular biology techniques to identify mechanisms behind apoptosis resulting from a zinc deficiency. Specifically, I characterized zinc’s involvement in growth factor signaling pathways, as well as the molecular mechanisms behind iron accrual secondary to a zinc deficiency

St. Louis, Missouri, Us

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Doctor Of Philosophy (Ph.D.), Nutritional Biology With Designated Emphasis In Biotechnology

Bachelor Of Science (Bs), Physiology