Clear Gene is on a mission to leave no tumor behind. We use genomics and machine learning to ensure that breast cancers are treated completely.

After completing my M.D., I studied breast cancer genomics and molecular epigenetics at Stanford School of Medicine. My work helped pioneer the combination of higher-order chromatin biology and human genomics. The human genome project had given us a sequence of letters, but the genome is not linear; it has a complex three-dimensional structure. I used our emerging understanding of higher-order genome structure to investigate human diseases.I developed the first genome-wide analysis that combined chromatin structure and the population genetics. 3DAS combines 3-Dimensional genome maps with Genome-Wide Association Studies. 3DAS uncovered some really cool interactions between breast cancer genes, and we still don’t understand how genes that are far apart on a chromosome come together to regulate each other inside the nucleus. But thanks to 3DAS, we now know that this mechanism is prevalent in breast cancer, and we have a new tool to hunt them down.As a postdoc, I generated $2.3+ million in funding. My projects were supported by the National Institutes of Health, the U.S. Department of Defense, and the Lucile Packard Foundation.• The NIH Transformative Research Award supports innovation that promises to transform your field and an adjacent field.• The DoD Breast Cancer Idea Award supported 3DAS.• The New Idea Grant from the Lucile Packard Foundation for Children’s Health used 3D genome maps to understand why patients with genetic deletions at one location have symptoms caused by genes at another location.These projects allowed me lead a scientific team and build collaborations with Genentech, University of Pennsylvania, Albert Einstein College of Medicine, and UC Santa Cruz.Stanford also provided the opportunity to gain leadership experience outside of lab. I was elected to lead the Stanford Postdoctoral Association, and joined the Stanford School of Medicine Faculty Senate where I represented 2,000 of the nation’s most promising physicians and scientists.

• Series of three 2-month research rotations

• Inspired by a patient with Transmissible Spongiform Encephalopathy (“Prion Diseases”), I initiated an investigation of conditions that could generate de novo misfolded proteins

• Investigated role of Junctional Adhesion Molecules (JAMs) in Sertoli cells during spermatogenesis

• Designed and independently executed a 4-year study of parasite-host interactions• Presented results at platform sessions during regional and international meetings• Resulted in first author publication as an undergraduate